Sugi Predict

Sugi Predict / Compounds / Chamazulene

Chamazulene

Chamazulene

SCHEMBL29562128

CCc1ccc(C)c2ccc(C)c-2c1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.50
▸ ALDH1A1 P00352 2/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ TRPA1 O75762 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ CYP2A6 P11509 1/20 0.41
▸ HTR7 P34969 2/20 0.39
▸ LPL P06858 1/20 0.38
▸ LIPG Q9Y5X9 1/20 0.38
▸ ALOX5 P09917 1/20 0.37
▸ PTGS1 P23219 1/20 0.37
▸ PTGS2 P35354 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chamazulene SCHEMBL180449 1.00 LMNA (0.50) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL27995671 0.82 EGFR (0.39) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL5165125 0.82 CNR1 (0.55) LMNAHTR7LPLLIPGALOX5
SCHEMBL29144243 0.80 ALDH1A1 (0.38) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL29144241 0.80 ALDH1A1 (0.38) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL26968759 0.79 SKP2 (0.56) LMNAALDH1A1SMN1; SMN2NPC1MAPK1
SCHEMBL2185559 0.78 ALDH1A1 (0.41) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL29441542 0.77 TRPA1 (0.48) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL270167 0.77 TRPA1 (0.48) LMNAALDH1A1SMN1; SMN2NPC1MAPT
SCHEMBL26968743 0.77 SKP2 (0.50) LMNAALDH1A1KDM4ELPLLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3281620-B1 PHOTOPROTECTIVE COMPOSITION BASED ON A 2-ALKOXY-4-ALKYL KETONE PHENOL COMPOUND OREAL (FR) 2026-02-18 — — EP disclosed
US-20250249059-A1 PLANT BASED HONEY COMPOSITION Melibio, Inc. 2025-08-07 — — US disclosed
US-20250163006-A1 New Coolants, and Preparations Containing Same SYMRISE AG (DE) 2025-05-22 — — US disclosed
EP-3663366-B1 USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS SYMRISE AG (DE) 2025-01-08 — — EP disclosed
EP-4469439-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2024-12-04 — — EP disclosed
CN-117838555-A Application of chamazulene as sun-proof synergistic agent and sun-proof synergistic composition and cosmetic 多特瑞(上海)生物科技有限公司 2024-04-09 — — CN disclosed
CN-114957081-B Azulene compounds, intermediates, preparation method and application thereof 中国科学院上海有机化学研究所 2024-04-05 — — CN disclosed
CN-117561081-A Application of CYP450 inhibitor in inhibiting or killing mites and treating xerophthalmia 广州珍实视界生物医药科技有限公司 2024-02-13 — — CN disclosed
WO-2024011228-A1 PLANT BASED HONEY COMPOSITION Melibio, Inc. (US) 2024-01-11 — — WO disclosed
US-20240000746-A1 New Cooling Agents and Preparations Containing Them SYMRISE AG (DE) 2024-01-04 — — US disclosed
EP-3675809-B1 USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS BASF SE (DE) 2023-09-27 — — EP disclosed
EP-4247791-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2023-09-27 — — EP disclosed
WO-2023144326-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-08-03 — — WO disclosed
WO-2023143741-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-08-03 — — WO disclosed
US-11617762-B2 Compositions comprising sulfated polysaccharides SEANERGY DERMATOLOGY LTD. (IL) 2023-04-04 — — US disclosed
US-11458083-B2 Cosmetic and/or dermatological composition containing a merocyanine derivative comprising specific polar groups consisting of hydroxyl- and ether-functionalities L'OREAL (FR) 2022-10-04 — — US disclosed
WO-2022175111-A1 METAL COMPLEXES HAVING 4-H, 6-H OR 8-H DIHYDROAZULENYL LIGANDS AND USE THEREOF UMICORE AG & CO. KG (DE) 2022-08-25 — — WO disclosed
US-20220249543-A1 Trona Based Therapeutic Compositions and Use and Manufacture Thereof Moxiyo, LLC 2022-08-11 — — US disclosed
WO-2022105986-A1 NOVEL COOLING AGENTS AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 — — WO disclosed
WO-2022106452-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11458083-B2 Cosmetic and/or dermatological composition containing a merocyanine derivative comprising specific polar groups consisting of hydroxyl- and ether-functionalities KRT18, LAGE3, TYR LMNA 186/4885ALDH1A1 1018/4885SMN1; SMN2 4825/4885
US-20240000746-A1 New Cooling Agents and Preparations Containing Them TTPA, TREH, TAS2R45 LMNA 2062/4885ALDH1A1 1658/4885SMN1; SMN2 1307/4885
US-20250163006-A1 New Coolants, and Preparations Containing Same TTR, TAS2R5, TAS2R50 LMNA 3005/4885ALDH1A1 811/4885SMN1; SMN2 643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.