Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29645738 | 0.86 | NTRK1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29645837 | 0.84 | EGFR (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29645786 | 0.84 | MAPT (0.42) | — | |
| SCHEMBL29646148 | 0.83 | LMNA (0.39) | SCN9A | |
| SCHEMBL29645682 | 0.83 | ADORA3 (0.40) | P2RX7 | |
| SCHEMBL29645803 | 0.83 | POLB (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29645914 | 0.82 | NR1H2 (0.40) | P2RX7 | |
| SCHEMBL29646083 | 0.81 | MAPT (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29645597 | 0.80 | TRPA1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29646123 | 0.79 | P2RX7 (0.33) | P2RX7DHODHHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114466850-A | [1,2,4] triazolo [1,5-C ] quinazolin-5-amines | 拜耳股份有限公司 | 2022-05-10 | — | — | CN | claimed |