Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25699756 | 0.67 | HTT (0.34) | HTTKMT2ADYRK1A | |
| SCHEMBL20099798 | 0.67 | HTT (0.34) | HTTKMT2ADYRK1ASMN1; SMN2CHEK1 | |
| SCHEMBL29694373 | 0.65 | GSK3A (0.37) | KDR | |
| SCHEMBL29809560 | 0.64 | HTT (0.32) | HTTKMT2A | |
| SCHEMBL15290415 | 0.64 | HTT (0.39) | HTTKMT2ADYRK1ASMN1; SMN2CHEK1 | |
| SCHEMBL4201272 | 0.60 | ABHD6 (0.35) | HTTKMT2AABHD6 | |
| SCHEMBL30471092 | 0.60 | ABHD6 (0.35) | HTTKMT2AABHD6 | |
| SCHEMBL5120809 | 0.60 | ADRA2A (0.47) | HTTKMT2ADYRK1ASMN1; SMN2CDK5 | |
| SCHEMBL9403398 | 0.60 | PRNP (0.46) | HTTKMT2ADYRK1ASMN1; SMN2MAPT | |
| SCHEMBL1500697 | 0.59 | SMN1; SMN2 (0.48) | HTTKMT2ADYRK1ASMN1; SMN2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486264-B2 | Bicyclic HPK1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-12-02 | — | — | US | disclosed |
| EP-3947373-B1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-14 | — | — | EP | disclosed |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486264-B2 | Bicyclic HPK1 inhibitors | PCK1, PGK1, PDXK | HTT 1731/4885KMT2A 2847/4885DYRK1A 2022/4885 |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | PCK1, PGK1, PDXK | HTT 1731/4885KMT2A 2847/4885DYRK1A 2022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.