SCHEMBL2969849

SCHEMBL2969849

CNC(=O)CC(NC(=O)O)C1CCN(Cc2ccc(-c3ccc(F)cc3)cc2Cl)CC1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.42
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C19 P33261 1/20 0.41
RECQL P46063 1/20 0.41
P2RX7 Q99572 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
CXCR3 P49682 1/20 0.39
MCHR1 Q99705 2/20 0.38
DRD2 P14416 1/20 0.38
DRD4 P21917 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
SIGMAR1 Q99720 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2972291 0.91 ALDH1A1 (0.47) ACHEALDH1A1TDP1MCHR1NPSR1
SCHEMBL2982132 0.83 POLB (0.51) ALDH1A1DRD4SIGMAR1
SCHEMBL2982160 0.80 MCHR1 (0.49) ACHEMCHR1
SCHEMBL2975024 0.79 ARG1 (0.44) ALDH1A1P2RX7SIGMAR1
SCHEMBL2970163 0.77 SIGMAR1 (0.49) ALDH1A1SIGMAR1
Hydrochloric Acid SCHEMBL2971258 0.76 SIGMAR1 (0.48) SIGMAR1
SCHEMBL2969854 0.76 ACHE (0.42) ACHEMCHR1DRD2DRD4
SCHEMBL3592322 0.76 POLB (0.50) ACHEALDH1A1CYP3A4CYP2D6CYP2C19
SCHEMBL2975513 0.75 DRD2 (0.46) ALDH1A1DRD2
SCHEMBL2983164 0.75 CCR8 (0.55) ALDH1A1TDP1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7781590-B2 Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors SANOFI-AVENTIS (FR) 2010-08-24 US disclosed
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021403-A1 PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, CNR2 ACHE 455/4885ALDH1A1 1076/4885CYP3A4 688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.