Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 known ✓ | P47900 | 8/20 | 0.83 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.59 |
| ▸ | P2RY2 known ✓ | P41231 | 1/20 | 0.59 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.59 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 5/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 0.59 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.59 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.59 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.59 |
| ▸ | LDHA | P00338 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543337 | 1.00 | P2RY1 (0.83) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| Potassium Ion SCHEMBL28579922 | 0.99 | P2RY1 (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| Potassium Ion SCHEMBL29723936 | 0.99 | P2RY1 (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL31441159 | 0.92 | P2RY1 (0.80) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL18785113 | 0.92 | POLB (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL4546151 | 0.92 | POLB (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL11927745 | 0.92 | POLB (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL7882477 | 0.92 | POLB (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL543475 | 0.92 | POLB (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 | |
| SCHEMBL48174 | 0.92 | POLB (0.81) | P2RY1ENPP1POLBP2RY11DNPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022127326-A1 | PROTEIN AND MULTI-STAGE POROUS METAL-ORGANIC FRAMEWORK COMPLEX, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 华南理工大学 | 2022-06-23 | — | — | WO | claimed |
| WO-2022127326-A1 | PROTEIN AND MULTI-STAGE POROUS METAL-ORGANIC FRAMEWORK COMPLEX, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 华南理工大学 | 2022-06-23 | — | — | WO | disclosed |