Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26314517 | 0.75 | PARP1 (0.47) | TNKS2PARP1ELANEALDH1A1TNKS | |
| SCHEMBL5477868 | 0.75 | MAPT (0.53) | TNKS2PARP1PDE3BPDE3AALDH1A1 | |
| SCHEMBL47352 | 0.72 | PARP1 (1.00) | TNKS2PARP1ALDH1A1TNKSQTRT1 | |
| SCHEMBL31483744 | 0.72 | KMT2A (0.46) | TNKS2PARP1PDE3BPDE3AELANE | |
| SCHEMBL8621956 | 0.71 | PARP1 (0.96) | TNKS2PARP1ALDH1A1TNKSQTRT1 | |
| SCHEMBL8621967 | 0.71 | PARP1 (0.96) | TNKS2PARP1ALDH1A1TNKSQTRT1 | |
| SCHEMBL4944696 | 0.68 | TNKS2 (0.51) | TNKS2PARP1PDE3BPDE3AELANE | |
| SCHEMBL530191 | 0.68 | ALDH1A1 (0.58) | TNKS2PARP1ALDH1A1TNKSKMT2A | |
| SCHEMBL30293081 | 0.68 | ALDH1A1 (0.58) | TNKS2PARP1ALDH1A1TNKSKMT2A | |
| SCHEMBL146072 | 0.68 | ELANE (1.00) | ELANENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026037755-A1 | NEW METHYLQUINAZOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2026-02-19 | — | — | WO | disclosed |
| EP-4073065-B1 | NEW METHYLQUINAZOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-02-19 | — | — | EP | disclosed |
| EP-4483882-A2 | NEW METHYLQUINAZOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-01-01 | — | — | EP | disclosed |
| US-12116349-B2 | Methylquinazolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2024-10-15 | — | — | US | disclosed |
| US-20240174621-A1 | METHYLQUINAZOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-05-30 | — | — | US | disclosed |
| EP-4073065-A1 | NEW METHYLQUINAZOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2022-10-19 | — | — | EP | disclosed |
| US-20220298119-A1 | METHYLQUINAZOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2022-09-22 | — | — | US | disclosed |
| JP-2022124458-A | NEW METHYLQUINAZOLINONE DERIVATIVES | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 2022-08-25 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298119-A1 | METHYLQUINAZOLINONE DERIVATIVES | SLC10A1, ABCB11, CYP11B2 | TNKS2 2405/4885PARP1 2495/4885PDE3B 33/4885 |
| US-20240174621-A1 | METHYLQUINAZOLINONE DERIVATIVES | CYP3A5, KCNQ1, GDI2 | TNKS2 2349/4885PARP1 2687/4885PDE3B 28/4885 |
| US-12116349-B2 | Methylquinazolinone derivatives | SLC10A1, ABCB11, CYP11B2 | TNKS2 2405/4885PARP1 2495/4885PDE3B 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.