Icosabutate

Icosabutate

SCHEMBL298718

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCO[C@@H](CC)C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
CYP19A1 P11511 4/20 0.51
F7 P08709 3/20 0.51
F3 P13726 3/20 0.51
MAPT P10636 3/20 0.51
OXER1 Q8TDS5 3/20 0.51
PPARG P37231 3/20 0.51
PTGS1 P23219 2/20 0.51
KMT2A Q03164 2/20 0.51
PPARD Q03181 2/20 0.51
PPARA Q07869 2/20 0.51
CYP3A4 P08684 2/20 0.51
ALOX15 P16050 2/20 0.51
HSD17B10 Q99714 2/20 0.51
TDP1 Q9NUW8 2/20 0.51
NR1I2 O75469 2/20 0.51
PTGS2 P35354 2/20 0.51
FFAR1 O14842 2/20 0.51
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Icosabutate SCHEMBL2785319 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL15996134 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL3678942 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL298719 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL289973 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL18334790 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL3678946 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL15996220 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL21585131 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT
Icosabutate SCHEMBL15995662 1.00 ALDH1A1 (0.51) ALDH1A1CYP19A1F7F3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427415-B1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS BASF AS (NO) 2019-03-20 EP claimed
US-8735436-B2 Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas PRONOVA BIOPHARMA NORGE AS (NO) 2014-05-27 US claimed
US-20120122940-A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS PRONOVA BIOPHARMA NORGE AS (NO) 2012-05-17 US claimed
EP-2248798-A1 Novel lipid compounds Pronova BioPharma Norge AS (NO) 2010-11-10 EP claimed
US-12599580-B2 Composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same BASF AS (NO) 2026-04-14 US disclosed
US-12440466-B2 Fatty acid derivatives for treating non-alcoholic steatohepatitis BASF AS (NO) 2025-10-14 US disclosed
EP-3720431-B1 FATTY ACID DERIVATIVES FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS BASF AS (NO) 2024-10-30 EP disclosed
US-20240325336-A1 COMBINATION THERAPIES COMPRISING OXYGEN-CONTAINING STRUCTURALLY ENHANCED FATTY ACIDS FOR TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS NORTHSEA THERAPEUTICS B.V. (NL) 2024-10-03 US disclosed
US-20240156769-A1 FATTY ACID DERIVATIVES FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS BASF AS (NO) 2024-05-16 US disclosed
US-11925614-B2 Fatty acid derivatives for treating non-alcoholic steatohepatitis BASF AS (NO) 2024-03-12 US disclosed
US-20230090432-A1 COMPOSITION COMPRISING A LIPID COMPOUND, A TRIGLYCERIDE, AND A SURFACTANT, AND METHODS OF USING THE SAME PRONOVA BIOPHARMA NORGE AS (NO) 2023-03-23 US disclosed
US-11351139-B2 Composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same BASF AS (NO) 2022-06-07 US disclosed
US-20120122940-A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS PRONOVA BIOPHARMA NORGE AS (NO) 2012-05-17 US disclosed
WO-2012059818-A1 METHODS OF TREATMENT USING LIPID COMPOUNDS PRONOVA BIOPHARMA NORGE AS (NO) 2012-05-10 WO disclosed
EP-2427415-A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS Pronova BioPharma Norge AS (NO) 2012-03-14 EP disclosed
WO-2010128401-A9 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS PRONOVA BIOPHARMA NORGE AS (NO) 2011-12-08 WO disclosed
WO-2010128401-A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS PRONOVA BIOPHARMA NORGE AS (NO) 2010-11-11 WO disclosed
WO-2010128401-A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS PRONOVA BIOPHARMA NORGE AS (NO) 2010-11-11 WO disclosed
EP-2248798-A1 Novel lipid compounds Pronova BioPharma Norge AS (NO) 2010-11-10 EP disclosed
EP-2248798-A1 Novel lipid compounds Pronova BioPharma Norge AS (NO) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240156769-A1 FATTY ACID DERIVATIVES FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS CPT1A, NR1H2, NR1H3 ALDH1A1 154/4885CYP19A1 229/4885F7 2878/4885
US-11351139-B2 Composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same LIPA, SCD5, SBDS ALDH1A1 1748/4885CYP19A1 835/4885F7 751/4885
US-20120122940-A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS FFAR2, FFAR3, FFAR1 ALDH1A1 695/4885CYP19A1 1476/4885F7 1019/4885
US-20240325336-A1 COMBINATION THERAPIES COMPRISING OXYGEN-CONTAINING STRUCTURALLY ENHANCED FATTY ACIDS FOR TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS ACACA, PC, ACACB ALDH1A1 525/4885CYP19A1 849/4885F7 4060/4885
US-12599580-B2 Composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same LIPA, LIPC, LIPG ALDH1A1 3488/4885CYP19A1 1347/4885F7 1015/4885
US-20230090432-A1 COMPOSITION COMPRISING A LIPID COMPOUND, A TRIGLYCERIDE, AND A SURFACTANT, AND METHODS OF USING THE SAME LIPA, SCD5, SBDS ALDH1A1 1748/4885CYP19A1 835/4885F7 751/4885
US-12440466-B2 Fatty acid derivatives for treating non-alcoholic steatohepatitis CPT1A, NR1H2, NR1H3 ALDH1A1 154/4885CYP19A1 229/4885F7 2878/4885
US-11925614-B2 Fatty acid derivatives for treating non-alcoholic steatohepatitis CPT1A, NR1H3, NR1H2 ALDH1A1 162/4885CYP19A1 252/4885F7 2781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.