SCHEMBL29936733

SCHEMBL29936733

COC(=O)c1c(F)c(F)c(-c2cc(C)cc(C)c2)c(F)c1F

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 3/20 0.54
ALDH1A1 P00352 4/20 0.44
KMT2A Q03164 3/20 0.44
POLB P06746 1/20 0.44
TSHR P16473 2/20 0.42
MAPK1 P28482 2/20 0.42
MEN1 O00255 2/20 0.41
MAPT P10636 3/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
CYP3A4 P08684 2/20 0.39
ACHE P22303 1/20 0.39
HSD17B10 Q99714 2/20 0.38
LMNA P02545 1/20 0.37
CISD2 Q8N5K1 1/20 0.37
HPGD P15428 1/20 0.37
GLO1 Q04760 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29936713 0.82 HSD17B1 (0.41) CNR2ALDH1A1KMT2APOLBTSHR
SCHEMBL29936962 0.79 MAPT (0.48) ALDH1A1KMT2APOLBTSHRMAPK1
SCHEMBL505248 0.77 LMNA (0.57) ALDH1A1KMT2ATSHRMAPK1MEN1
SCHEMBL25332785 0.77 SLC6A3 (0.50) ALDH1A1KMT2APOLBTSHRMAPK1
SCHEMBL522175 0.77 TSHR (0.61) ALDH1A1KMT2ATSHRMAPK1MEN1
SCHEMBL29936878 0.75 ALDH1A1 (0.50) ALDH1A1KMT2APOLBMAPTTDP1
SCHEMBL29106646 0.75 LMNA (0.58) ALDH1A1KMT2APOLBTSHRMEN1
SCHEMBL1719721 0.74 TSHR (0.59) ALDH1A1TSHRMAPK1MAPTCYP3A4
SCHEMBL17563220 0.74 ALDH1A1 (0.36) CNR2ALDH1A1KMT2ATSHRMEN1
SCHEMBL29936772 0.74 ALPL (0.48) ALDH1A1KMT2APOLBTSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010600-B Method for synthesizing polyfluoroaryl carboxylic acid compound based on aryl fluorocarbon bond carboxylation reaction 四川大学 2023-11-17 CN disclosed
CN-115010600-A Method for synthesizing polyfluoroaryl carboxylic acid compounds based on aryl fluorocarbon bond carboxylation reaction 四川大学 2022-09-06 CN disclosed