Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LIPE | Q05469 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11351938 | 0.81 | MAPT (0.69) | LMNAMAPTNPSR1LIPETHRB | |
| SCHEMBL493936 | 0.80 | KIF11 (0.45) | LMNATHRB | |
| SCHEMBL6983743 | 0.77 | MAPT (0.55) | LMNAMAPTNPSR1THRBSCN9A | |
| SCHEMBL30689322 | 0.76 | LMNA (0.47) | LMNAMAPTNPSR1THRBSCN9A | |
| SCHEMBL8576331 | 0.74 | MAPT (0.65) | LMNAMAPTNPSR1LIPETHRB | |
| SCHEMBL4728325 | 0.74 | KDM4E (0.62) | LMNAMAPTNPSR1LIPETHRB | |
| SCHEMBL906222 | 0.74 | LMNA (0.63) | LMNAMAPTNPSR1LIPETHRB | |
| SCHEMBL21652204 | 0.74 | RAB9A (0.67) | LMNAMAPTNPSR1LIPETHRB | |
| SCHEMBL11383589 | 0.74 | LIPE (0.65) | LMNAMAPTNPSR1LIPETHRB | |
| SCHEMBL9272113 | 0.74 | THRB (0.76) | LMNAMAPTNPSR1LIPETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |