Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29694430 | 0.89 | ALDH1A1 (0.56) | ALDH1A1HSPD1BLMHSPE1KDM4E | |
| Citric Acid SCHEMBL10793339 | 0.87 | ALDH1A1 (0.54) | ALDH1A1HSPD1BLMHSPE1KDM4E | |
| Citric Acid SCHEMBL18189763 | 0.85 | HSPD1 (0.55) | ALDH1A1HSPD1BLMHSPE1MAPT | |
| Citric Acid SCHEMBL29563289 | 0.85 | HSPD1 (0.55) | ALDH1A1HSPD1BLMHSPE1MAPT | |
| Citric Acid SCHEMBL3816409 | 0.85 | HSPD1 (0.55) | ALDH1A1HSPD1BLMHSPE1MAPT | |
| Citric Acid SCHEMBL30150820 | 0.85 | HSPD1 (0.55) | ALDH1A1HSPD1BLMHSPE1MAPT | |
| Citric Acid SCHEMBL429386 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HSPD1BLMHSPE1KDM4E | |
| Citric Acid SCHEMBL6435477 | 0.83 | ALDH1A1 (0.79) | ALDH1A1HSPD1BLMHSPE1KDM4E | |
| SCHEMBL29544360 | 0.82 | TET2 (0.47) | ALDH1A1HSPD1BLMHSPE1TSHR | |
| Citric Acid SCHEMBL10006598 | 0.82 | ALDH1A1 (0.52) | ALDH1A1HSPD1BLMHSPE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260026953-A1 | BALLOON DELIVERY SYSTEM FOR THE IMPLANT DEPLOYMENT | UNIV NORTHWESTERN (US) | 2026-01-29 | — | — | US | disclosed |
| WO-2024020566-A2 | BALLOON DELIVERY SYSTEM FOR THE IMPLANT DEPLOYMENT | NORTHWESTERN UNIVERSITY (US) | 2024-01-25 | — | — | WO | disclosed |
| US-20240009357-A1 | 3D PRINTING OF BIOMEDICAL IMPLANTS | NORTHWESTERN UNIVERSITY | 2024-01-11 | — | — | US | disclosed |
| US-11565026-B2 | 3D printing of biomedical implants | NORTHWESTERN UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260026953-A1 | BALLOON DELIVERY SYSTEM FOR THE IMPLANT DEPLOYMENT | SBDS, SMC3, BAG3 | MEN1 4770/4885HRH1 3928/4885ALDH1A1 4463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.