Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | XPO1 | O14980 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27611205 | 0.90 | MAPT (0.58) | MAPTGAAELANEALDH1A1TRPV1 | |
| SCHEMBL9863135 | 0.88 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2GPR35KMT2A | |
| SCHEMBL3903964 | 0.84 | XPO1 (0.51) | MAPTGAAELANEALDH1A1PARP1 | |
| SCHEMBL197307 | 0.83 | TRPV1 (0.61) | ELANEALDH1A1PARP1TRPV1SMN1; SMN2 | |
| SCHEMBL29443099 | 0.83 | TRPV1 (0.61) | ELANEALDH1A1PARP1TRPV1SMN1; SMN2 | |
| SCHEMBL2007367 | 0.83 | TDP1 (0.53) | MAPTGAAELANEALDH1A1PARP1 | |
| SCHEMBL1704844 | 0.82 | ABCB1 (0.47) | MAPTGAAALDH1A1SMN1; SMN2GPR35 | |
| SCHEMBL11365918 | 0.82 | MAPT (0.51) | MAPTGAAELANEALDH1A1TRPV1 | |
| SCHEMBL11365920 | 0.82 | MAPT (0.51) | MAPTGAAELANEALDH1A1TRPV1 | |
| SCHEMBL11631222 | 0.81 | PARP1 (0.51) | MAPTGAAELANEALDH1A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624010-B2 | Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway | AC IMMUNE SA (CH) | 2026-05-12 | — | — | US | disclosed |
| EP-4168395-B1 | DIHYDROOXAZOLE AND THIOUREA OR UREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2026-03-25 | — | — | EP | disclosed |
| US-20230250070-A1 | DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2023-08-10 | — | — | US | disclosed |
| US-20230250070-A1 | DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2023-08-10 | — | — | US | disclosed |
| EP-4168395-A1 | DIHYDROOXAZOLE AND THIOUREA OR UREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC Immune SA (CH) | 2023-04-26 | — | — | EP | disclosed |
| CN-115768754-A | Dihydrooxazole and thiourea or urea derivatives that modulate NLRP3 inflammasome pathways | AC免疫有限公司 | 2023-03-07 | — | — | CN | disclosed |
| WO-2021255279-A1 | D I H YD ROOXAZO LE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2021-12-23 | — | — | WO | disclosed |
| WO-2021255279-A1 | D I H YD ROOXAZO LE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2021-12-23 | — | — | WO | disclosed |
| CN-108699106-B | Novel trifluoromethylpropionamide derivatives as HTRA1 inhibitors | 豪夫迈·罗氏有限公司 | 2021-11-30 | — | — | CN | disclosed |
| US-11014963-B2 | Trifluoromethylpropanamide derivatives as HTRA1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-7723336-B2 | Fused heterocyclic compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-05-25 | — | — | US | disclosed |
| US-20080045536-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2008-02-21 | — | — | US | disclosed |
| US-20070043000-A1 | Immunosuppresive effects of pteridine derivatives | 4 AZA BIOSCIENCE NV (BE) | 2007-02-22 | — | — | US | disclosed |
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| EP-1636232-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA Bioscience nv (BE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104005-A2 | IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES | 4 AZA BIOSCIENCE NV (BE) | 2004-12-02 | — | — | WO | disclosed |
| EP-1479682-A1 | Immunosuppressive effects of pteridine derivatives | 4 AZA Bioscience nv (BE) | 2004-11-24 | — | — | EP | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
| CN-1306523-A | Substituted 6-aryl-3-thioxo-5-(thi) oxo-2,3,4,5-tetrahydro-1,2,4-triazines | BASF AG (DE) | 2001-08-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043000-A1 | Immunosuppresive effects of pteridine derivatives | TPMT, FKBP5, RRP15 | MAPT 378/4885GAA 3004/4885ELANE 4800/4885 |
| US-12624010-B2 | Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway | NOD1, NLRP3, NLRP1 | MAPT 690/4885GAA 4296/4885ELANE 2480/4885 |
| US-11014963-B2 | Trifluoromethylpropanamide derivatives as HTRA1 inhibitors | HTRA1, HTR3E, HTR1F | MAPT 3299/4885GAA 4005/4885ELANE 98/4885 |
| US-20080045536-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | MAP3K3, MAP3K2, MAP4K3 | MAPT 3886/4885GAA 4483/4885ELANE 4047/4885 |
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | MAPT 4597/4885GAA 4576/4885ELANE 24/4885 |
| US-20230250070-A1 | DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | NLRP3, NOD1, NLRP1 | MAPT 2088/4885GAA 3719/4885ELANE 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.