Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30201042 | 0.74 | MTNR1A (0.56) | MTNR1AMTNR1BALDH1A1MAPTRAB9A | |
| SCHEMBL30201393 | 0.68 | MTNR1A (0.48) | MTNR1AMTNR1B | |
| SCHEMBL30200758 | 0.67 | MTNR1A (0.47) | MTNR1AMTNR1BALDH1A1LMNAKMT2A | |
| SCHEMBL30201055 | 0.67 | ALDH1A1 (0.47) | MTNR1AMTNR1BALDH1A1MAPTRAB9A | |
| SCHEMBL9052050 | 0.65 | TRPA1 (0.42) | MTNR1AMTNR1BALDH1A1LMNAPKM | |
| SCHEMBL19164743 | 0.63 | DPP7 (0.36) | ALDH1A1MAPTRAB9ALMNAMEN1 | |
| SCHEMBL1453904 | 0.63 | L3MBTL1 (0.45) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL24926752 | 0.62 | MAPT (0.46) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL585722 | 0.61 | MAOA (0.42) | MTNR1AMTNR1BALDH1A1MAPTLMNA | |
| SCHEMBL1674517 | 0.61 | MAPT (0.58) | ALDH1A1MAPTLMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023028086-A1 | COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |