Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | ATF1 | P18846 | 4/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24951146 | 1.00 | WDR5 (0.47) | WDR5ATF1NFKB1ALDH1A1KDM4E | |
| SCHEMBL24951831 | 0.92 | ALDH1A1 (0.46) | WDR5ATF1NFKB1ALDH1A1KDM4E | |
| SCHEMBL30202682 | 0.92 | ALDH1A1 (0.46) | WDR5ATF1NFKB1ALDH1A1KDM4E | |
| SCHEMBL30202826 | 0.86 | EP300 (0.45) | ATF1NFKB1NPC1MEN1KMT2A | |
| SCHEMBL30202837 | 0.86 | NFKB1 (0.50) | WDR5ATF1NFKB1ALDH1A1KDM4E | |
| SCHEMBL24951126 | 0.86 | NFKB1 (0.50) | WDR5ATF1NFKB1ALDH1A1KDM4E | |
| SCHEMBL24951472 | 0.86 | NFKB1 (0.46) | ATF1NFKB1ALDH1A1KDM4ERAB9A | |
| SCHEMBL24951630 | 0.78 | ALDH1A1 (0.50) | ATF1NFKB1ALDH1A1KDM4ERAB9A | |
| SCHEMBL30202869 | 0.78 | ALDH1A1 (0.50) | ATF1NFKB1ALDH1A1KDM4ERAB9A | |
| SCHEMBL24952254 | 0.75 | RAB9A (0.47) | NFKB1ALDH1A1KDM4ERAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4376845-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |