Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CES1 | P23141 | 5/20 | 0.43 |
| ▸ | CES2 | O00748 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368972 | 0.76 | ALDH1A1 (0.42) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL1219464 | 0.74 | ALDH1A1 (0.42) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL535862 | 0.72 | CES1 (0.48) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL144974 | 0.70 | CES1 (0.52) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL314447 | 0.69 | — | — | |
| SCHEMBL24662981 | 0.69 | ALDH1A1 (0.39) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL15024069 | 0.69 | MAPT (0.39) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL6545293 | 0.69 | CES1 (0.39) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL8745554 | 0.68 | TDP1 (0.52) | ALDH1A1CES1CES2TSHRDAO | |
| SCHEMBL5582134 | 0.68 | TDP1 (0.46) | ALDH1A1CES1CES2TSHRDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159267-A | Novel silyl ester azetidine-2-sulfenate intermediates and process for preparing desacetoxycephalosporins | ELI LILLY AND COMPANY (US) | 1979-06-26 | — | — | US | claimed |
| WO-2021074452-A1 | COMBINATION PREPARATIONS OF 3-N-FORMYLHYDROXYLAMINOPROPYL PHOSPHONIC ACID DERIVATIVES OR 3-N-ACETYLHYDROXYLAMINOPROPYL PHOSPHONIC ACID DERIVATIVES WITH CLINDAMYCIN AND ARTESUNATE | DMG DEUTSCHE MALARIA GMBH (DE) | 2021-04-22 | — | — | WO | disclosed |
| EP-2590651-B1 | NEW DRUG COMBINATIONS FOR THE TREATMENT OF MALARIA | BIOAGENCY AG (DE) | 2018-06-27 | — | — | EP | disclosed |
| US-20150190418-A1 | COMBINATION PREPARATIONS OF 3-N-FORMYL HYDROXY AMINO PROPYL PHOSPHONIC ACID DERIVATIVES OR 3-N-ACETYL HYDROXY AMINO PROPYL PHOSPHONIC ACID DERIVATIVES TOGETHER WITH SPECIAL PHARMACEUTICAL ACTIVE INGREDIENTS | JOMAA PHARMAKA GMBH (DE) | 2015-07-09 | — | — | US | disclosed |
| EP-2397475-B1 | 4, 4' disubstituted 4H-cyclopentadithiophene and new methods for synthesising the same | IMEC (BE) | 2014-11-12 | — | — | EP | disclosed |
| US-20130231296-A1 | NEW DRUG COMBINATIONS FOR THE TREATMENT OF MALARIA | BIOAGENCY AG (DE) | 2013-09-05 | — | — | US | disclosed |
| EP-2590651-A1 | NEW DRUG COMBINATIONS FOR THE TREATMENT OF MALARIA | BioAgency AG (DE) | 2013-05-15 | — | — | EP | disclosed |
| US-8329923-B2 | 4, 4′ disubstituted 4H-cyclopentadithiophene and new methods for synthesizing the same | IMEC (BE) | 2012-12-11 | — | — | US | disclosed |
| WO-2012004324-A1 | NEW DRUG COMBINATIONS FOR THE TREATMENT OF MALARIA | BIOAGENCY AG (DE) | 2012-01-12 | — | — | WO | disclosed |
| EP-2404601-A1 | New drug combinations for the treatment of Malaria | BioAgency AG (DE) | 2012-01-11 | — | — | EP | disclosed |
| EP-1071409-B1 | USE OF ORGANOPHOSPHORIC COMPOUNDS FOR THE THERAPEUTIC AND PREVENTATIVE TREATMENT OF INFECTIONS | BIOAGENCY AG (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-1140952-B1 | ORGANO-PHOSPHORUS COMPOUNDS AND THEIR UTILIZATION | BIOAGENCY AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| US-20030144249-A1 | Use of organophosphorous compounds for producing a medicament for treating infections | JOMAA PHARMAKA GMBH (DE) | 2003-07-31 | — | — | US | disclosed |
| US-6534489-B1 | Organophosphorus compounds and the use thereof | JOMAA PHARMAKA GMBH (DE) | 2003-03-18 | — | — | US | disclosed |
| US-20030045746-A1 | Phosphorous organic compounds and their use | JOMAA PHARMAKA GMBH (DE) | 2003-03-06 | — | — | US | disclosed |
| US-20030036533-A1 | Phosphorous organic compounds and their use | JOMAA PHARMAKA GMBH (DE) | 2003-02-20 | — | — | US | disclosed |
| EP-1133500-B1 | ORGANOPHOSPHOROUS COMPOUNDS AND THE USE THEREOF | JOMAA PHARMAKA GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001094358-A1 | ORGANOPHOSPHOROUS HYDROXAMIC ACID DERIVATIVES USED AS HERBICIDES | JOMAA PHARMAKA GMBH (DE) | 2001-12-13 | — | — | WO | disclosed |
| US-4159267-A | Novel silyl ester azetidine-2-sulfenate intermediates and process for preparing desacetoxycephalosporins | ELI LILLY AND COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-3944545-A | Process for preparing desacetoxycephalosporins | ELI LILLY AND COMPANY (US) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144249-A1 | Use of organophosphorous compounds for producing a medicament for treating infections | PHPT1, PPM1D, BPNT1 | ALDH1A1 1560/4885CES1 235/4885CES2 474/4885 |
| US-20030045746-A1 | Phosphorous organic compounds and their use | PPM1D, PFAS, PPM1F | ALDH1A1 2555/4885CES1 417/4885CES2 1044/4885 |
| US-20030036533-A1 | Phosphorous organic compounds and their use | PPM1D, PFAS, PPM1F | ALDH1A1 2555/4885CES1 417/4885CES2 1044/4885 |
| US-20130231296-A1 | NEW DRUG COMBINATIONS FOR THE TREATMENT OF MALARIA | FPR3, PFN1, PFKP | ALDH1A1 2730/4885CES1 2634/4885CES2 3101/4885 |
| US-20150190418-A1 | COMBINATION PREPARATIONS OF 3-N-FORMYL HYDROXY AMINO PROPYL PHOSPHONIC ACID DERIVATIVES OR 3-N-ACETYL HYDROXY AMINO PROPYL PHOSPHONIC ACID DERIVATIVES TOGETHER WITH SPECIAL PHARMACEUTICAL ACTIVE INGREDIENTS | FPR3, FPR1, AANAT | ALDH1A1 2096/4885CES1 2607/4885CES2 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.