Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26584242 | 0.89 | NPC1 (0.82) | NPC1RAB9AHTR7PTPN1SMN1; SMN2 | |
| SCHEMBL11686001 | 0.89 | SMN1; SMN2 (0.62) | NPC1RAB9AHTR7SMN1; SMN2KDM4E | |
| SCHEMBL13564338 | 0.88 | NPC1 (0.81) | NPC1RAB9AHTR7PTPN1SMN1; SMN2 | |
| SCHEMBL8272050 | 0.84 | NPC1 (0.62) | NPC1RAB9AHTR7PTPN1SMN1; SMN2 | |
| SCHEMBL3141694 | 0.83 | SMN1; SMN2 (0.56) | NPC1RAB9AHTR7SMN1; SMN2KDM4E | |
| SCHEMBL2490498 | 0.81 | HTR7 (0.78) | NPC1RAB9AHTR7PTPN1SMN1; SMN2 | |
| SCHEMBL315309 | 0.81 | RAB9A (0.69) | NPC1RAB9AHTR7PTPN1SMN1; SMN2 | |
| SCHEMBL822848 | 0.81 | KMT2A (0.70) | NPC1RAB9ASMN1; SMN2KDM4EHPGD | |
| SCHEMBL8532385 | 0.81 | HSD17B3 (0.67) | NPC1RAB9APTPN1SMN1; SMN2KDM4E | |
| SCHEMBL8533892 | 0.81 | SMN1; SMN2 (0.55) | RAB9ASMN1; SMN2KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115975178-A | Preparation method of polyaryletherketone resin with alkyl structure in main chain, polyaryletherketone resin with alkyl structure in main chain and application | 中国科学院大连化学物理研究所 | 2023-04-18 | — | — | CN | claimed |
| CN-115975179-A | Preparation method of alkyl structure-containing polyaryletherketone resin, alkyl structure-containing polyaryletherketone resin and application | 中国科学院大连化学物理研究所 | 2023-04-18 | — | — | CN | claimed |
| CN-115975178-A | Preparation method of polyaryletherketone resin with alkyl structure in main chain, polyaryletherketone resin with alkyl structure in main chain and application | 中国科学院大连化学物理研究所 | 2023-04-18 | — | — | CN | disclosed |
| CN-115975179-A | Preparation method of alkyl structure-containing polyaryletherketone resin, alkyl structure-containing polyaryletherketone resin and application | 中国科学院大连化学物理研究所 | 2023-04-18 | — | — | CN | disclosed |
| EP-3156398-A1 | AGONISTS OF THE CHEMOKINE RECEPTOR CXCR3 | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2017-04-19 | — | — | EP | disclosed |
| US-8609713-B2 | Pyrrole derivatives and their methods of use | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-8012970-B2 | Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis process and uses thereof | UNIVERSTA' DEGLI STUDI DI SIENA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-8012970-B2 | Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis process and uses thereof | UNIVERSTA' DEGLI STUDI DI SIENA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-20110144109-A1 | Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof | BIAVA MARIANGELA | 2011-06-16 | — | — | US | disclosed |
| US-20110144109-A1 | Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof | BIAVA MARIANGELA | 2011-06-16 | — | — | US | disclosed |
| US-7910581-B2 | Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl] methyl}-4-methylpiperazine, synthesis process and uses thereof | POMPEI (10%), RAFFAELLO (IT) | 2011-03-22 | — | — | US | disclosed |
| US-20100216748-A1 | Pyrrole Derivatives and Their Methods of Use | ABBOTT LABORATORIES (US) | 2010-08-26 | — | — | US | disclosed |
| US-7741364-B2 | Neuronal nicotinic acetylcholine receptor modulators; such as ethyl 1-[4-(aminosulfonyl)phenyl]-5-(4-bromophenyl)-2-methyl-1H-pyrrole-3-carboxylate | ABBOTT LABORATORIES (US) | 2010-06-22 | — | — | US | disclosed |
| EP-2172451-A2 | Derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine, synthesis and use thereof | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2010-04-07 | — | — | EP | disclosed |
| US-20090281094-A1 | Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof | POMPEI (10%), RAFFAELLO (IT) | 2009-11-12 | — | — | US | disclosed |
| US-20090281094-A1 | Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof | POMPEI (10%), RAFFAELLO (IT) | 2009-11-12 | — | — | US | disclosed |
| EP-2041085-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | Abbott Laboratories (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080064695-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | ABBVIE INC. | 2008-03-13 | — | — | US | disclosed |
| WO-2008002974-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-01-03 | — | — | WO | disclosed |
| EP-0739340-A1 | PHENYL HETEROCYCLES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-10-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064695-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | PYCR1, PPOX, DHPS | NPC1 3463/4885RAB9A 2814/4885HTR7 2682/4885 |
| US-20090281094-A1 | Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof | DHPS, RRP12, MRPS22 | NPC1 2899/4885RAB9A 3860/4885HTR7 1495/4885 |
| US-20100216748-A1 | Pyrrole Derivatives and Their Methods of Use | PYCR1, PPOX, DHPS | NPC1 3463/4885RAB9A 2814/4885HTR7 2682/4885 |
| US-20110144109-A1 | Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof | DHPS, RRP12, MRPS22 | NPC1 2899/4885RAB9A 3860/4885HTR7 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.