Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.56 |
| ▸ | WNT3A | P56704 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16552778 | 0.91 | KMT2A (0.83) | KMT2AGSK3BCTNNB1WNT3ASMN1; SMN2 | |
| SCHEMBL11686001 | 0.91 | SMN1; SMN2 (0.62) | KMT2ASMN1; SMN2KDM4EHPGDNPC1 | |
| P-Xylene SCHEMBL28175467 | 0.88 | KMT2A (0.61) | KMT2ACTNNB1WNT3ASMN1; SMN2KDM4E | |
| SCHEMBL18132972 | 0.86 | KMT2A (0.58) | KMT2AGSK3BCTNNB1WNT3AMEN1 | |
| SCHEMBL8536042 | 0.85 | SMN1; SMN2 (0.53) | KMT2AGSK3BCTNNB1WNT3ASMN1; SMN2 | |
| SCHEMBL3141694 | 0.84 | SMN1; SMN2 (0.56) | KMT2ASMN1; SMN2KDM4EHPGDNPC1 | |
| SCHEMBL8269520 | 0.83 | KMT2A (0.77) | KMT2AGSK3BCTNNB1WNT3ASMN1; SMN2 | |
| Succinic Acid SCHEMBL8467793 | 0.83 | KMT2A (1.00) | KMT2AGSK3BCTNNB1WNT3ASMN1; SMN2 | |
| SCHEMBL16922187 | 0.83 | KMT2A (1.00) | KMT2AGSK3BCTNNB1WNT3ASMN1; SMN2 | |
| SCHEMBL8532385 | 0.83 | HSD17B3 (0.67) | KMT2ASMN1; SMN2KDM4EHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787484-B2 | Compositions and methods for treating cardiovascular disease | GENENTECH, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190177366-A1 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE | GENENTECH, INC. (US) | 2019-06-13 | — | — | US | disclosed |
| US-9580571-B2 | Aromatic acylation with cyclic anhydride for plasticizer production | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2017-02-28 | — | — | US | disclosed |
| US-9512296-B2 | Aromatic acylation with cyclic anhydride for plasticizer production | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2016-12-06 | — | — | US | disclosed |
| US-8703811-B2 | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase | GENZYME CORPORATION (US) | 2014-04-22 | — | — | US | disclosed |
| US-8674115-B2 | CRTH2 modulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20110286922-A1 | IMAGING AND RADIOTHERAPY METHODS | GENERAL ELECTRIC COMPANY | 2011-11-24 | — | — | US | disclosed |
| US-20110160371-A1 | AROMATIC ACYLATION WITH CYCLIC ANHYDRIDE FOR PLASTICIZER PRODUCTION | EXXONMOBILE RESEARCH AND ENGINEERING COMPANY (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110150834-A1 | CRTH2 MODULATORS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2011-06-23 | — | — | US | disclosed |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | GENZYME CORPORATION | 2011-06-02 | — | — | US | disclosed |
| US-7695863-B2 | rechargeable batteries having excellent battery cycle properties, electrical capacity and storage characteristic during charging, comprising electrodes and a nonaqueous electrolytic solution containing a dicarbonyl compound as an additive | UBE INDUSTRIES, LTD. (JP) | 2010-04-13 | — | — | US | disclosed |
| CN-100566005-C | The lithium secondary battery of nonaqueous electrolyte solution and this solution of use | UBE INDUSTRIES (JP) | 2009-12-02 | — | — | CN | disclosed |
| US-20090176777-A1 | Imidazo (1,2-a)Pyridin-3-YL-Acetic Acid Hydrazides, Proesses for Their Preparation and Pharmaceutical Uses Thereof | FERRER INTERNACIONAL, S.A. (ES) | 2009-07-09 | — | — | US | disclosed |
| US-20080102377-A1 | rechargeable batteries having excellent battery cycle properties, electrical capacity and storage characteristic during charging, comprising electrodes and a nonaqueous electrolytic solution containing a dicarbonyl compound as an additive | UBE INDUSTRIES, LTD (JP) | 2008-05-01 | — | — | US | disclosed |
| CN-101091283-A | Nonaqueous electrolytic solution and lithium secondary battery using the same | UBE INDUSTRIES (JP) | 2007-12-19 | — | — | CN | disclosed |
| EP-0592881-B1 | Process for producing optically active gamma-hydroxyketones | TAKASAGO PERFUMERY CO LTD (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5349107-A | Ruthenium optically active phosphine complex | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0592881-A2 | Process for producing optically active gamma-hydroxyketones | Takasago International Corporation (JP) | 1994-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160371-A1 | AROMATIC ACYLATION WITH CYCLIC ANHYDRIDE FOR PLASTICIZER PRODUCTION | ACAD11, ACOT7, ACOX3 | KMT2A 247/4885GSK3B 4689/4885CTNNB1 4876/4885 |
| US-20110130381-A1 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, MDH1 | KMT2A 1599/4885GSK3B 3118/4885CTNNB1 4468/4885 |
| US-20110286922-A1 | IMAGING AND RADIOTHERAPY METHODS | ALDH2, ALDH3A1, ALDH1A1 | KMT2A 1972/4885GSK3B 3759/4885CTNNB1 3163/4885 |
| US-20110150834-A1 | CRTH2 MODULATORS | HRH2, HRH1, NR1H2 | KMT2A 3695/4885GSK3B 3293/4885CTNNB1 2240/4885 |
| US-20090176777-A1 | Imidazo (1,2-a)Pyridin-3-YL-Acetic Acid Hydrazides, Proesses for Their Preparation and Pharmaceutical Uses Thereof | GABRA3, GABRA1, GABRA2 | KMT2A 895/4885GSK3B 1892/4885CTNNB1 3563/4885 |
| US-10787484-B2 | Compositions and methods for treating cardiovascular disease | PCSK9, PCSK7, PCSK6 | KMT2A 2277/4885GSK3B 94/4885CTNNB1 601/4885 |
| US-20190177366-A1 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE | PCSK9, PCSK7, PCSK6 | KMT2A 2277/4885GSK3B 94/4885CTNNB1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.