Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | S100A4 | P26447 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28252591 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL29379039 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL85604 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL30306150 | 0.80 | ALDH1A1 (0.67) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL8715422 | 0.79 | TSHR (0.54) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL31474855 | 0.78 | ALDH1A1 (0.70) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL1637306 | 0.78 | ALDH1A1 (0.70) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL307768 | 0.78 | TDP1 (0.61) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL17083672 | 0.78 | ALDH1A1 (0.53) | ALDH1A1HIF1ATSHRLMNAKMT2A | |
| SCHEMBL5839662 | 0.77 | ALDH1A1 (0.57) | ALDH1A1HIF1ATSHRLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102942530-A | Novel anti-tumor compound and medication composition thereof | WU CHUNYONG | 2013-02-27 | — | — | CN | claimed |
| US-8183383-B2 | Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2012-05-22 | — | — | US | claimed |
| US-20100197927-A1 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (JP) | 2010-08-05 | — | — | US | claimed |
| EP-2133342-A1 | PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR, PREPARATION METHODS AND USES THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2009-12-16 | — | — | EP | claimed |
| CN-113260691-B | Luminescent solar concentrator comprising dithienyl pyridine thiadiazole compound | 艾尼股份公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2023160638-A1 | RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2023-08-31 | — | — | WO | disclosed |
| US-11713314-B2 | Disubstituted diaryloxybenzoheterodiazole compounds | ENI S.P.A. (IT) | 2023-08-01 | — | — | US | disclosed |
| US-11706979-B2 | Disubstituted diaryloxybenzoheterodiazole compounds | ENI S.P.A. (IT) | 2023-07-18 | — | — | US | disclosed |
| EP-3737678-B1 | PROCESS FOR THE PREPARATION OF DISUBSTITUTED DIARYLOXYBENZOHETERODIAZOLE COMPOUNDS | ENI SPA (IT) | 2022-06-29 | — | — | EP | disclosed |
| US-20220165959-A1 | DISUBSTITUTED FLUOROARYLOXYBENZOHETERODIAZOLE COMPOUNDS | ENI S.P.A. (IT) | 2022-05-26 | — | — | US | disclosed |
| EP-3941995-A1 | DISUBSTITUTED FLUOROARYLOXYBENZOHETERODIAZOLE COMPOUNDS | ENI S.p.A. (IT) | 2022-01-26 | — | — | EP | disclosed |
| US-20210408393-A1 | Disubstituted Diaryloxybenzoheterodiazole Compounds | ENI S.P.A. (IT) | 2021-12-30 | — | — | US | disclosed |
| US-20100197927-A1 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (JP) | 2010-08-05 | — | — | US | disclosed |
| EP-2133342-A1 | PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR, PREPARATION METHODS AND USES THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2009-12-16 | — | — | EP | disclosed |
| CN-100415725-C | Pyrimidine compound and application thereof | SUMITOMO CHEMICAL CO (JP) | 2008-09-03 | — | — | CN | disclosed |
| US-7291730-B2 | Pyrimidine compounds and their use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-11-06 | — | — | US | disclosed |
| US-20050107609-A1 | Pyrimidine compounds and their use | SUMITOMO CHEMICAL COMPANY | 2005-05-19 | — | — | US | disclosed |
| US-6838463-B2 | Pyrimidine compounds and their use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-01-04 | — | — | US | disclosed |
| EP-1366026-B1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| CN-1478082-A | Pyrimidine compound and application thereof | ס�ѻ�ѧ��ҵ��ʽ���� | 2004-02-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210408393-A1 | Disubstituted Diaryloxybenzoheterodiazole Compounds | SCLY, NR2E3, CDK15 | ALDH1A1 1702/4885HIF1A 4421/4885TSHR 1708/4885 |
| US-11713314-B2 | Disubstituted diaryloxybenzoheterodiazole compounds | SCO2, NR3C2, CBR3 | ALDH1A1 3243/4885HIF1A 2754/4885TSHR 493/4885 |
| US-20050107609-A1 | Pyrimidine compounds and their use | TYMP, TYMS, UMPS | ALDH1A1 783/4885HIF1A 3805/4885TSHR 472/4885 |
| US-20220165959-A1 | DISUBSTITUTED FLUOROARYLOXYBENZOHETERODIAZOLE COMPOUNDS | LSS, DDC, HLCS | ALDH1A1 1241/4885HIF1A 2744/4885TSHR 3538/4885 |
| US-11706979-B2 | Disubstituted diaryloxybenzoheterodiazole compounds | SCLY, NR2E3, CDK15 | ALDH1A1 1702/4885HIF1A 4421/4885TSHR 1708/4885 |
| US-20100197927-A1 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof | PTPA, PTPN7, PTPN5 | ALDH1A1 2010/4885HIF1A 2494/4885TSHR 1386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.