Xanthine

Xanthine

SCHEMBL30410232

O=c1nc2nc[nH]c2c([O-])[nH]1.[Na+]

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Xanthine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
XDH known ✓ P47989 3/20 0.37
PNP P00491 1/20 0.47
ALDH1A1 P00352 1/20 0.45
DPP4 P27487 1/20 0.41
GRIA1 P42261 1/20 0.41
GRIA2 P42262 1/20 0.41
GRIA3 P42263 1/20 0.41
GRIA4 P48058 1/20 0.41
GDA Q9Y2T3 2/20 0.40
PDPK1 O15530 1/20 0.39
CDK2 P24941 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11492860 0.76 PNP (0.49) PNPALDH1A1DPP4GRIA1GRIA2
Isoguanine SCHEMBL8591972 0.74 PNP (0.56) PNPALDH1A1DPP4GRIA1GRIA2
SCHEMBL31685532 0.71 PNP (0.45) PNPALDH1A1DPP4GRIA1GRIA2
SCHEMBL31685246 0.71 XDH (0.46) PNPALDH1A1DPP4GRIA1GRIA2
SCHEMBL31685398 0.67 GDA (0.61) PNPALDH1A1GDAXDH
Isoguanine SCHEMBL20477064 0.67 PNP (0.79) PNPALDH1A1DPP4GRIA1GRIA2
Guanine SCHEMBL28330713 0.66 PNP (0.93) PNPALDH1A1DPP4GRIA1GRIA2
Isoguanine SCHEMBL10380136 0.65 GDA (0.49) PNPALDH1A1DPP4GRIA1GRIA2
Isoguanine SCHEMBL5885760 0.65 PNP (0.45) PNPALDH1A1DPP4GRIA1GRIA2
SCHEMBL10605226 0.64 PNP (0.57) PNPALDH1A1GRIA1GRIA2GRIA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4436792-B1 RUBBER MIXTURE COMPRISING A RAPID VULCANISATION ACCELERATOR MICHELIN & CIE (FR) 2025-09-24 EP claimed
EP-4436792-A1 RUBBER MIXTURE COMPRISING A RAPID VULCANISATION ACCELERATOR COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2024-10-02 EP claimed
EP-4436436-A1 FOOTWEAR SOLE MADE OF RUBBER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2024-10-02 EP claimed
WO-2023094523-A1 RUBBER MIXTURE COMPRISING A RAPID VULCANISATION ACCELERATOR COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2023-06-01 WO claimed
WO-2023094230-A1 FOOTWEAR SOLE MADE OF RUBBER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2023-06-01 WO claimed
EP-4436792-B1 RUBBER MIXTURE COMPRISING A RAPID VULCANISATION ACCELERATOR MICHELIN & CIE (FR) 2025-09-24 EP disclosed
EP-4436792-A1 RUBBER MIXTURE COMPRISING A RAPID VULCANISATION ACCELERATOR COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2024-10-02 EP disclosed
EP-4436436-A1 FOOTWEAR SOLE MADE OF RUBBER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2024-10-02 EP disclosed
WO-2023094523-A1 RUBBER MIXTURE COMPRISING A RAPID VULCANISATION ACCELERATOR COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2023-06-01 WO disclosed
WO-2023094230-A1 FOOTWEAR SOLE MADE OF RUBBER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2023-06-01 WO disclosed