Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314842 | 0.77 | ALDH1A1 (0.40) | HPGDALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL25349620 | 0.77 | PDPK1 (0.42) | HPGDALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL17265808 | 0.74 | ALDH1A1 (0.52) | HPGDALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL23101036 | 0.71 | NPSR1 (0.39) | HPGDKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4302790 | 0.69 | ALDH1A1 (0.43) | HPGDALDH1A1LMNAAPOBEC3GKDM4E | |
| SCHEMBL31224733 | 0.69 | HPGD (0.43) | HPGDALDH1A1LMNAAPOBEC3GMAPT | |
| SCHEMBL13373332 | 0.67 | MAPT (0.48) | HPGDALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2258481 | 0.66 | NQO2 (0.46) | HPGDALDH1A1LMNAAPOBEC3GMAPT | |
| SCHEMBL18089319 | 0.66 | HPGD (0.47) | HPGDALDH1A1LMNAAPOBEC3GKDM4E | |
| SCHEMBL620396 | 0.65 | SMN1; SMN2 (0.48) | HPGDALDH1A1LMNAAPOBEC3GKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4626881-A1 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-10-08 | — | — | EP | disclosed |
| US-20240254114-A1 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-01 | — | — | US | disclosed |
| WO-2024118858-A1 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-06-06 | — | — | WO | disclosed |
| US-20220289732-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | NOVARTIS AG (CH) | 2022-09-15 | — | — | US | disclosed |
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION | 2010-09-02 | — | — | US | disclosed |
| US-4424272-A | CARBONYLOXYBENZYL QUATERNARY AMMONIUM-SUBSTITUTED ACRYLAMIDE POLYMER | POLAROID CORPORATION (US) | 1984-01-03 | — | — | US | disclosed |
| US-4297431-A | POLYMERS OF ACRYLIC ESTERS AS OVERCOATS OR TIMING LAYERS FOR LIGHT SENSITIVE ELEMENTS | POLAROID CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289732-A1 | HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS | WDR5, WDR77, WDR1 | HPGD 3053/4885ALDH1A1 2452/4885LMNA 3967/4885 |
| US-20240254114-A1 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS | DGAT2, DGAT1, ACAT2 | HPGD 997/4885ALDH1A1 984/4885LMNA 3214/4885 |
| US-20100222345-A1 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS | OPRL1, OPRM1, OPRK1 | HPGD 1627/4885ALDH1A1 3109/4885LMNA 4551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.