SCHEMBL3049404

SCHEMBL3049404

CC(C)N(C)S(=O)(=O)NC(=O)c1ccc(F)c([N+](=O)[O-])c1Cl

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 12/20 0.41
FLT4 P35916 12/20 0.41
KDR P35968 12/20 0.41
SCN9A Q15858 7/20 0.39
ALDH1A1 P00352 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3059734 0.77 SCN9A (0.43) FLT1FLT4KDRSCN9A
SCHEMBL3080870 0.74 CLPP (0.50) ALDH1A1SMN1; SMN2
SCHEMBL28789360 0.72 KCNH2 (0.38) ALDH1A1SMN1; SMN2
SCHEMBL3676531 0.72 HPGD (0.55) SCN9AALDH1A1SMN1; SMN2
SCHEMBL3086799 0.71 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2
SCHEMBL3052008 0.71 ALDH1A1 (0.40) FLT1FLT4KDRALDH1A1SMN1; SMN2
SCHEMBL713577 0.68 SCN9A (0.46) SCN9A
SCHEMBL31118371 0.67 SCN9A (0.45) SCN9A
SCHEMBL27871304 0.66 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2
SCHEMBL714409 0.65 HDAC6 (0.43) SCN9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9920002-B2 Methods for producing sulfonic acid diamides BASF SE (DE) 2018-03-20 US disclosed
US-20120310010-A1 Method for producing sulfonamides BASF SE (DE) 2012-12-06 US disclosed
US-8263806-B2 Method for producing sulfonamides BASF SE (DE) 2012-09-11 US disclosed
US-20100228054-A1 Method for Producing Sulfonamides BASF SE (DE) 2010-09-09 US disclosed
US-20100222586-A1 Methods for Producing Sulfonic Acid Diamides BASF SE (DE) 2010-09-02 US disclosed
EP-1957443-A2 METHOD FOR PRODUCING SULFONAMIDES BASF SE (DE) 2008-08-20 EP disclosed
WO-2007063028-A2 METHOD FOR PRODUCING SULFONAMIDES BASF SE (DE) 2007-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222586-A1 Methods for Producing Sulfonic Acid Diamides CBR3, SQOR, SRM FLT1 2007/4885FLT4 2157/4885KDR 965/4885
US-20100228054-A1 Method for Producing Sulfonamides STS, MSRB3, SQOR FLT1 4454/4885FLT4 4225/4885KDR 4580/4885
US-20120310010-A1 Method for producing sulfonamides MSRB3, STS, TST FLT1 4651/4885FLT4 4379/4885KDR 4437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.