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Sugi Predict / Compounds / SCHEMBL3056906

SCHEMBL3056906

SCHEMBL3056906

CCOC(=O)C[C@@H](C(=O)COC(=O)c1c(Cl)cccc1Cl)N(C(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)[C@@H](C)C(N)=O

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CASP1 P29466 8/20 0.43
▸ CTSL P07711 3/20 0.42
▸ CTSB P07858 3/20 0.42
▸ CTSS P25774 3/20 0.42
▸ CTSK P43235 2/20 0.42
▸ CASP3 P42574 5/20 0.41
▸ CASP6 P55212 4/20 0.41
▸ CASP8 Q14790 4/20 0.41
▸ ELANE P08246 1/20 0.38
▸ CCR1 P32246 1/20 0.38
▸ BACE1 P56817 1/20 0.37
▸ CASP7 P55210 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3056903 0.80 CASP3 (0.57) CASP1CTSBCTSKCASP3CASP6
SCHEMBL7367055 0.80 CASP3 (0.57) CASP1CTSBCTSKCASP3CASP6
SCHEMBL18143146 0.78 CTSB (0.48) CASP1CTSLCTSBCTSSCTSK
SCHEMBL7364559 0.76 CASP3 (0.48) CASP1CASP3CASP6CASP8
SCHEMBL7365589 0.76 CASP3 (0.48) CASP1CASP3CASP6CASP8
SCHEMBL9415817 0.73 CASP3 (0.46) CASP1CASP3CASP6CASP8CASP7
SCHEMBL13914069 0.73 CASP3 (0.50) CASP1CTSLCTSBCTSSCTSK
SCHEMBL8247253 0.73 CASP3 (0.67) CASP1CASP3CASP6CASP8
SCHEMBL7745119 0.73 CASP3 (0.67) CASP1CASP3CASP6CASP8
SCHEMBL29802628 0.72 CASP1 (0.74) CASP1CASP3CASP6CASP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9353218-B2 Kit for multifunctional compounds forming crosslinked biomaterials ANGIOTECH PHARMACEUTICALS, INC. 2016-05-31 — — US disclosed
US-20130289235-A1 MULTIFUNCTIONAL COMPOUNDS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE ANGIOTECH PHARMACEUTICALS, INC. (CA) 2013-10-31 — — US disclosed
US-8486437-B2 Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use ANGIOTECH PHARMACEUTICALS (US), INC. (US) 2013-07-16 — — US disclosed
US-20130012683-A1 MULTIFUNCTIONAL COMPOUNDS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE ANGIOTECH PHARMACEUTICALS (US), INC. (US) 2013-01-10 — — US disclosed
US-8303973-B2 Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use ANGIOTECH PHARMACEUTICALS (US), INC. (US) 2012-11-06 — — US disclosed
US-20100268288-A1 ELECTRICAL DEVICES AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2010-10-21 — — US disclosed
US-20100092536-A1 IMPLANTABLE SENSORS AND IMPLANTABLE PUMPS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2010-04-15 — — US disclosed
US-20090226500-A1 SUTURES AND ANTI-SCARRING AGENTS ANGIOTECH PHARMACEUTICALS, INC (CA) 2009-09-10 — — US disclosed
US-20090214652-A1 SOFT TISSUE IMPLANTS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2009-08-27 — — US disclosed
US-20090203632-A1 COMPOSITIONS AND METHODS FOR TREATING CONTRACTURE ANGIOTECH INTERNATIONAL AG (CH) 2009-08-13 — — US disclosed
US-20050149157-A1 Electrical devices and anti-scarring agents ANGIOTECH INTERNATIONAL AG (CH) 2005-07-07 — — US disclosed
US-20050143817-A1 Medical implants and anti-scarring agents ANGIOTECH INTERNATIONAL AG (CH) 2005-06-30 — — US disclosed
WO-2005051452-A2 POLYMER COMPOSITIONS AND METHODS FOR THEIR USE ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005051316-A2 POLYMER COMPOSITIONS AND METHODS FOR THEIR USE ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005051483-A2 ELECTRICAL DEVICES AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005051871-A2 IMPLANTABLE SENSORS AND IMPLANTABLE PUMPS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005051444-A2 SOFT TISSUE IMPLANTS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005051451-A2 ELECTRICAL DEVICES AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005051232-A2 SOFT TISSUE IMPLANTS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2005-06-09 — — WO disclosed
WO-2005046516-A2 MEDICAL IMPLANTS AND ANTI-SCARRING AGENTS ANGIOTECH INTERNATIONAL AG (CH) 2005-05-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203632-A1 COMPOSITIONS AND METHODS FOR TREATING CONTRACTURE COL2A1, FN1, TNNC1 CASP1 4213/4885CTSL 2653/4885CTSB 1966/4885
US-20090214652-A1 SOFT TISSUE IMPLANTS AND ANTI-SCARRING AGENTS MMP1, COL2A1, FN1 CASP1 3130/4885CTSL 542/4885CTSB 230/4885
US-20090226500-A1 SUTURES AND ANTI-SCARRING AGENTS COL1A1, COL2A1, COL14A1 CASP1 1478/4885CTSL 1936/4885CTSB 1011/4885
US-20100092536-A1 IMPLANTABLE SENSORS AND IMPLANTABLE PUMPS AND ANTI-SCARRING AGENTS MMP1, CDKN1A, MKI67 CASP1 530/4885CTSL 1088/4885CTSB 573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.