Sugi Predict

Sugi Predict / Compounds / SCHEMBL30571306

SCHEMBL30571306

SCHEMBL30571306

COc1cc(Cl)ccc1[Mg]Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.46
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ HSP90AA1 P07900 1/20 0.37
▸ HSP90AB1 P08238 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.37
▸ HTR3E A5X5Y0 2/20 0.37
▸ HTR3B O95264 2/20 0.37
▸ HTR3A P46098 2/20 0.37
▸ HTR3D Q70Z44 2/20 0.37
▸ HTR3C Q8WXA8 2/20 0.37
▸ SLC6A2 P23975 2/20 0.36
▸ SLC6A4 P31645 2/20 0.36
▸ SLC6A3 Q01959 2/20 0.36
▸ KCNH2 Q12809 1/20 0.36
▸ TTR P02766 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ FLT1 P17948 1/20 0.36
▸ FLT4 P35916 1/20 0.36
▸ KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15140350 1.00 TRPV4 (0.46) TRPV4MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL4493751 0.84 TRPV4 (0.42) TRPV4MEN1KMT2AALDH1A1HTR3E
SCHEMBL31235573 0.82 TRPV4 (0.47) TRPV4MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL31235539 0.80 TRPV4 (0.46) TRPV4MEN1KMT2AHSP90AA1HSP90AB1
SCHEMBL30792548 0.78 CA12 (0.56) MEN1KMT2AALDH1A1NPC1KDM4E
SCHEMBL26118583 0.78 ACHE (0.56) MEN1KMT2AALDH1A1SMN1; SMN2NPC1
SCHEMBL1416677 0.78 CA12 (0.56) MEN1KMT2AALDH1A1NPC1KDM4E
SCHEMBL5637248 0.76 NFE2L2 (0.38) MEN1KMT2ASMN1; SMN2KDM4E
SCHEMBL7964461 0.76 S1PR4 (0.33) ALDH1A1SLC6A4KCNH2LMNASMN1; SMN2
SCHEMBL2127233 0.73 TRPV4 (0.55) TRPV4MEN1KMT2AALDH1A1HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12398136-B2 Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors VENTUS THERAPEUTICS U.S., INC. (US) 2025-08-26 — — US disclosed
US-20250257077-A1 BRIDGED BICYCLIC HETEROCYCLOALKYL PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS VENTUS THERAPEUTICS U.S., INC. 2025-08-14 — — US disclosed
US-20250250270-A1 COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF VENTUS THERAPEUTICS U S INC (US) 2025-08-07 — — US disclosed
US-20250236620-A1 PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS VENTUS THERAPEUTICS U S INC (US) 2025-07-24 — — US disclosed
US-12281112-B2 Compounds for inhibiting NLRP3 and uses thereof VENTUS THERAPEUTICS U.S., INC. (US) 2025-04-22 — — US disclosed
EP-4499638-A1 PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES Ventus Therapeutics U.S., Inc. (US) 2025-02-05 — — EP disclosed
US-12195460-B2 Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors VENTUS THERAPEUTICS U.S., INC. (US) 2025-01-14 — — US disclosed
US-20240383896-A1 PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS VENTUS THERAPEUTICS U.S., INC. 2024-11-21 — — US disclosed
US-20240360127-A1 PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES VENTUS THERAPEUTICS U.S., INC. 2024-10-31 — — US disclosed
US-20240360128-A1 COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF VENTUS THERAPEUTICS U.S., INC. 2024-10-31 — — US disclosed
WO-2023183943-A1 PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES VENTUS THERAPEUTICS U.S., INC. (US) 2023-09-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12195460-B2 Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors NLRP3, NLRP1, PYCARD TRPV4 2942/4885MEN1 4534/4885KMT2A 3631/4885
US-20250257077-A1 BRIDGED BICYCLIC HETEROCYCLOALKYL PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS NLRP3, NLRP1, NOD1 TRPV4 2630/4885MEN1 3689/4885KMT2A 4059/4885
US-20240383896-A1 PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS NLRP3, NLRP1, NOD1 TRPV4 633/4885MEN1 3690/4885KMT2A 4157/4885
US-20240360127-A1 PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES NLRP3, NLRP1, PYCARD TRPV4 2990/4885MEN1 4605/4885KMT2A 3678/4885
US-20240360128-A1 COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF NLRP3, NLRP1, PYCARD TRPV4 3736/4885MEN1 4547/4885KMT2A 4662/4885
US-20250236620-A1 PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS NLRP3, NLRP1, PYCARD TRPV4 2942/4885MEN1 4534/4885KMT2A 3631/4885
US-12281112-B2 Compounds for inhibiting NLRP3 and uses thereof NLRP3, NLRP1, PYCARD TRPV4 3736/4885MEN1 4547/4885KMT2A 4662/4885
US-12398136-B2 Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors NLRP3, NLRP1, NOD1 TRPV4 633/4885MEN1 3690/4885KMT2A 4157/4885
US-20250250270-A1 COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF NLRP3, NLRP1, PYCARD TRPV4 3736/4885MEN1 4547/4885KMT2A 4662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.