Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 6/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.37 |
| ▸ | MMP7 | P09237 | 4/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP10 | P09238 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | MMP14 | P50281 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077608 | 0.89 | PTGES (0.42) | ADAMTS4PTGESNMT1MMP1MMP2 | |
| SCHEMBL3097439 | 0.89 | ADAMTS4 (0.40) | ADAMTS4PTGESNMT1MMP1MMP2 | |
| SCHEMBL3087168 | 0.88 | ADAMTS4 (0.39) | ADAMTS4PTGESNMT1ROCK2HSD17B1 | |
| SCHEMBL3084477 | 0.84 | MMP1 (0.39) | ADAMTS4PTGESNMT1MMP1MMP2 | |
| SCHEMBL3086081 | 0.84 | ROCK2 (0.40) | ADAMTS4PTGESNMT1MMP1MMP2 | |
| SCHEMBL4793214 | 0.84 | NAMPT (0.41) | ADAMTS4NMT1MMP1MMP2MMP3 | |
| SCHEMBL4795906 | 0.82 | NMT1 (0.48) | ADAMTS4NMT1 | |
| SCHEMBL8777638 | 0.82 | MMP2 (0.40) | ADAMTS4NMT1MMP1MMP2MMP3 | |
| SCHEMBL3082269 | 0.82 | NMT1 (0.46) | ADAMTS4NMT1MMP1MMP2MMP3 | |
| Hydrochloric Acid SCHEMBL3097044 | 0.81 | NMT1 (0.48) | ADAMTS4NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234378-A1 | ALKYLSULFONAMIDE-SUBSTITUTED TRIAZOLES AS MATRIX METALLOPROTEASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-09-16 | — | — | US | claimed |
| US-20100234378-A1 | ALKYLSULFONAMIDE-SUBSTITUTED TRIAZOLES AS MATRIX METALLOPROTEASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234378-A1 | ALKYLSULFONAMIDE-SUBSTITUTED TRIAZOLES AS MATRIX METALLOPROTEASE INHIBITORS | MMP3, MMP11, MMP13 | ADAMTS4 31/4885PTGES 702/4885NMT1 2646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.