SCHEMBL30774563

SCHEMBL30774563

N#Cc1ccc(-c2cncc3c2OCCN3C(=O)Cc2cccc(C(F)(F)F)c2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR142 Q7Z601 1/20 0.46
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ RIPK1 Q13546 6/20 0.42
▸ NTRK1 P04629 1/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ LCK P06239 1/20 0.42
▸ YES1 P07947 1/20 0.42
▸ RET P07949 1/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ CYP2C8 P10632 1/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ KIT P10721 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42
▸ EIF2AK2 P19525 1/20 0.42
▸ AXL P30530 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ NEK4 P51957 1/20 0.42
▸ MAP3K9 P80192 1/20 0.42
▸ MAP3K10 Q02779 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30774594 0.90 STAT3 (0.42) GPR142RIPK1FAAHNAAAROCK1
SCHEMBL30773988 0.89 NAAA (0.40) RIPK1NTRK1CYP3A4CYP2D6NTRK3
SCHEMBL30773980 0.87 RIPK1 (0.41) RIPK1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL30774028 0.87 NAAA (0.40) RIPK1EIF2AK2EIF2AK1EIF2AK3FAAH
SCHEMBL30774488 0.86 RIPK1 (0.48) GPR142MEN1KMT2ARIPK1NTRK1
SCHEMBL30773976 0.85 VNN1 (0.41) VNN1PTGDR2
SCHEMBL30773978 0.85 FAAH (0.43) MEN1KMT2ARIPK1EIF2AK3FAAH
SCHEMBL30773967 0.83 NAAA (0.40) EIF2AK3FAAHNAAASLC22A12
SCHEMBL30774365 0.83 STAT3 (0.41) NAAAVNN1PTGDR2SLC22A12
SCHEMBL30774026 0.82 NAAA (0.40) EIF2AK3FAAHNAAASLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092074-A1 Annelated Pyridines as Steroidogenesis Inhibitors, Preparation Method and Use Thereof GUANGZHOU VINNOCENT PHARMACEUTICAL LTD (CN) 2026-04-02 — — US claimed
EP-4574830-A1 ANNELATED PYRIDINE STEROID SYNTHETASE INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF Guangzhou Vinnocent Pharmaceutical Limited (CN) 2025-06-25 — — EP claimed
US-20260092074-A1 Annelated Pyridines as Steroidogenesis Inhibitors, Preparation Method and Use Thereof GUANGZHOU VINNOCENT PHARMACEUTICAL LTD (CN) 2026-04-02 — — US disclosed
EP-4574830-A1 ANNELATED PYRIDINE STEROID SYNTHETASE INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF Guangzhou Vinnocent Pharmaceutical Limited (CN) 2025-06-25 — — EP disclosed
WO-2024061371-A1 ANNELATED PYRIDINE STEROID SYNTHETASE INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF 广州威诺森医药科技有限公司 2024-03-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092074-A1 Annelated Pyridines as Steroidogenesis Inhibitors, Preparation Method and Use Thereof STS, NR5A1, CYP21A2 GPR142 3680/4885MEN1 2219/4885KMT2A 2400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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