SCHEMBL3090779

SCHEMBL3090779

COc1ccc(Cc2c[nH]c3ccccc23)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 4/20 0.71
KMT2A Q03164 7/20 0.68
MEN1 O00255 6/20 0.68
HTR6 P50406 1/20 0.65
MAPT P10636 4/20 0.61
AHR P35869 3/20 0.61
CYP3A4 P08684 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
SMN1; SMN2 Q16637 2/20 0.57
ALDH1A1 P00352 2/20 0.57
KDM4E B2RXH2 1/20 0.57
SSTR1 P30872 1/20 0.55
SSTR4 P31391 1/20 0.55
SSTR3 P32745 1/20 0.55
NPC1 O15118 1/20 0.54
POLB P06746 1/20 0.54
RAB9A P51151 1/20 0.54
TP53 P04637 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
GABRP O00591 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7372873 0.86 KMT2A (0.69) GPR84KMT2AMEN1MAPTTDP1
SCHEMBL31744749 0.84 GPR84 (0.70) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL21399377 0.84 GPR84 (0.70) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL3086792 0.82 MEN1 (0.74) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL147220 0.82 KMT2A (0.74) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL21383512 0.81 MEN1 (0.59) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL30648199 0.81 MEN1 (1.00) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL553605 0.81 MEN1 (1.00) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL31744564 0.80 GPR84 (0.65) GPR84KMT2AMEN1HTR6MAPT
SCHEMBL28565162 0.79 MEN1 (0.70) GPR84KMT2AMEN1HTR6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250382268-A1 METHODS AND COMPOSITIONS FOR SELECTIVELY INHIBITING PATHOGENIC MICROBES CFD RES CORPORATION (US) 2025-12-18 US claimed
US-20250382268-A1 METHODS AND COMPOSITIONS FOR SELECTIVELY INHIBITING PATHOGENIC MICROBES CFD RES CORPORATION (US) 2025-12-18 US disclosed
US-20250382269-A1 METHODS AND COMPOSITIONS FOR SELECTIVELY INHIBITING PATHOGENIC MICROBES CFD RES CORPORATION (US) 2025-12-18 US disclosed
CN-103570697-B The method for preparing vilazodone and its intermediate 江苏先声药业有限公司 2017-09-15 CN disclosed
CN-104177283-B The method preparing bisindole methane derivative in the presence of amine salt 陕西师范大学 2016-08-17 CN disclosed
CN-103467354-B Method for preparing diindolyl methane derivatives UNIV SHAANXI NORMAL 2015-04-08 CN disclosed
CN-104177283-A Method for preparing bis (indolyl) methane derivative in presence of amine salt UNIV SHAANXI NORMAL 2014-12-03 CN disclosed
CN-103467354-A Method for preparing diindolyl methane derivatives UNIV SHAANXI NORMAL 2013-12-25 CN disclosed
US-8207134-B2 Fused ring spiroketal derivative and use thereof as anti-diabetic drug CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-06-26 US disclosed
US-20100234609-A1 FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS ANTI-DIABETIC DRUG CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2010-09-16 US disclosed
EP-2048152-A1 FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-04-15 EP disclosed
US-7071201-B2 Serotonin antagonism; muscle relaxant for myotonia; such as 1-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)-7-methoxy-1,2,3,4 -tetrahydroquinoline EISAI CO., LTD. (JP) 2006-07-04 US disclosed
CN-1204121-C 1,4-substituted cyclic amine derivatives EISAI CO LTD (JP) 2005-06-01 CN disclosed
EP-0976732-B1 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES EISAI CO LTD (JP) 2004-11-24 EP disclosed
US-6579881-B2 Indoles EISAI CO., LTD. (JP) 2003-06-17 US disclosed
US-6448243-B1 SEROTONIN ANTAGONIST FOR TREATING, AMELIORATING AND PREVENTING SPASTIC PARALYSIS OR CENTRAL MUSCLE RELAXANTS FOR AMELIORATING MYOTONIA EISAI CO., LTD. (JP) 2002-09-10 US disclosed
US-20020086999-A1 Certain quinoline derivatives EISAI CO., LTD. 2002-07-04 US disclosed
US-20020019531-A1 Indoles EISAI CO., LTD. 2002-02-14 US disclosed
CN-1253547-A 1,4-substituted cyclic amine derivatives EISAI CO LTD (JP) 2000-05-17 CN disclosed
EP-0976732-A1 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES Eisai Co., Ltd. (JP) 2000-02-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019531-A1 Indoles INMT, MUSK, MB GPR84 3231/4885KMT2A 1128/4885MEN1 424/4885
US-20100234609-A1 FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS ANTI-DIABETIC DRUG REN, WNK1, GCKR GPR84 2377/4885KMT2A 4219/4885MEN1 2579/4885
US-20250382269-A1 METHODS AND COMPOSITIONS FOR SELECTIVELY INHIBITING PATHOGENIC MICROBES CD14, MIF, NOD2 GPR84 4183/4885KMT2A 4633/4885MEN1 2402/4885
US-20020086999-A1 Certain quinoline derivatives CHRM1, CHRNA5, CHRNA4 GPR84 2417/4885KMT2A 1347/4885MEN1 574/4885
US-20250382268-A1 METHODS AND COMPOSITIONS FOR SELECTIVELY INHIBITING PATHOGENIC MICROBES CD14, MIF, NOD2 GPR84 4183/4885KMT2A 4633/4885MEN1 2402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.