SCHEMBL309198

SCHEMBL309198

CC(C)(C)Cn1cccn1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.38
TSHR P16473 2/20 0.36
AR P10275 1/20 0.36
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
NOS1 P29475 4/20 0.34
NOS3 P29474 1/20 0.34
CYP3A4 P08684 1/20 0.33
DAO P14920 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HTT P42858 1/20 0.32
BRD4 O60885 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14451165 0.86 FDPS (0.38) FDPSTSHRARGAAMAPT
SCHEMBL31211936 0.82 FDPS (0.36) FDPSTSHRARGAAMAPT
SCHEMBL1444746 0.82 FDPS (0.40) FDPSTSHRARGAAMAPT
SCHEMBL29268091 0.82 AR (0.37) FDPSTSHRARGAAMAPT
SCHEMBL16861331 0.82 FDPS (0.36) FDPSTSHRARGAAMAPT
SCHEMBL19222165 0.79 TSHR (0.36) FDPSTSHRARGAAMAPT
SCHEMBL21996407 0.79 FDPS (0.38) FDPSTSHRARGAAMAPT
SCHEMBL22210902 0.79 FDPS (0.38) FDPSTSHRARGAAMAPT
SCHEMBL31678596 0.79 FDPS (0.34) FDPSTSHRARGAAMAPT
SCHEMBL855608 0.77 DAO (0.38) FDPSTSHRGAAMAPTNOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4646410-A1 TUBULIN POLYMERIZATION INHIBITORS AB Science (FR) 2025-11-12 EP disclosed
WO-2024146923-A1 TUBULIN POLYMERIZATION INHIBITORS AB SCIENCE (FR) 2024-07-11 WO disclosed
US-20230365541-A1 INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2023-11-16 US disclosed
US-20230365584-A1 HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER SCHRÖDINGER, INC. 2023-11-16 US disclosed
US-20230365584-A1 HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER SCHRÖDINGER, INC. 2023-11-16 US disclosed
US-20230348450-A1 CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE GENZYME CORPORATION 2023-11-02 US disclosed
US-20230348450-A1 CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE GENZYME CORPORATION 2023-11-02 US disclosed
US-11767301-B2 Bi-functional molecules to degrade circulating proteins YALE UNIVERSITY (US) 2023-09-26 US disclosed
US-20230183213-A1 5-MEMBERED HETEROARYL CARBOXAMIDE COMPOUNDS FOR TREATMENT OF HBV ASSEMBLY BIOSCIENCES, INC. 2023-06-15 US disclosed
US-11319318-B2 Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2022-05-03 US disclosed
US-20080045568-A1 Novel high affinity quinoline-based kinase ligands SCHERING CORPORATION 2008-02-21 US disclosed
US-20070287705-A1 Crf Receptor Antagonists and Methods Relating Thereto NEUROCRINE BIOSCIENCES, INC. 2007-12-13 US disclosed
US-20070287705-A1 Crf Receptor Antagonists and Methods Relating Thereto NEUROCRINE BIOSCIENCES, INC. 2007-12-13 US disclosed
US-20070259904-A1 Bi-aryl meta-pyrimidine inhibitors of kinases TARGEGEN, INC. (US) 2007-11-08 US disclosed
US-20070259904-A1 Bi-aryl meta-pyrimidine inhibitors of kinases TARGEGEN, INC. (US) 2007-11-08 US disclosed
CN-101066950-A 4-amino-5-methylpyrazole derivatives and process for producing the same SANKYO AGRO CO LTD (JP) 2007-11-07 CN disclosed
CN-101062917-A 4-amino-5-methylpyrazole derivatives and process for producing the same SANKYO AGRO CO LTD (JP) 2007-10-31 CN disclosed
CN-101062918-A 4-amino-5-methylpyrazole derivatives and process for producing the same SANKYO AGRO CO LTD (JP) 2007-10-31 CN disclosed
CN-1732155-A 4-amino-5-methylpyrazole derivatives and process for producing the same SANKYO AGRO CO LTD (JP) 2006-02-08 CN disclosed
EP-1580189-A1 4-AMINO-5-METHYLPYRAZOLE DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF Sankyo Agro Company, Limited (JP) 2005-09-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11767301-B2 Bi-functional molecules to degrade circulating proteins MIF, ASGR1, FCGR2A FDPS 2297/4885TSHR 943/4885AR 4158/4885
US-20230365584-A1 HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER CDC7, BUB1B, CDK7 FDPS 1764/4885TSHR 4801/4885AR 3485/4885
US-20230183213-A1 5-MEMBERED HETEROARYL CARBOXAMIDE COMPOUNDS FOR TREATMENT OF HBV HCCS, HAVCR2, MAVS FDPS 1293/4885TSHR 3539/4885AR 3970/4885
US-20070287705-A1 Crf Receptor Antagonists and Methods Relating Thereto CRHR1, CRHR2, CRH FDPS 4253/4885TSHR 220/4885AR 335/4885
US-20230348450-A1 CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE BPGM, PGAM1, PGM2 FDPS 440/4885TSHR 4852/4885AR 4784/4885
US-20070259904-A1 Bi-aryl meta-pyrimidine inhibitors of kinases JAK2, TYK2, JAK3 FDPS 749/4885TSHR 1278/4885AR 2259/4885
US-11319318-B2 Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9 BRD9, BRD1, BRD2 FDPS 3899/4885TSHR 1182/4885AR 1592/4885
US-20080045568-A1 Novel high affinity quinoline-based kinase ligands CDKL2, CDK2, CDKL1 FDPS 3351/4885TSHR 4228/4885AR 3419/4885
US-20230365541-A1 INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF EZH2, BMI1, EZH1 FDPS 2042/4885TSHR 4365/4885AR 1567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.