Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10814747 | 0.90 | ALDH1A1 (0.51) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL8536622 | 0.90 | MERTK (0.51) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL30435204 | 0.90 | MERTK (0.51) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL2874199 | 0.90 | LMNA (0.50) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL2840001 | 0.87 | ALDH1A1 (0.49) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL4132806 | 0.87 | LMNA (0.48) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL310130 | 0.86 | LMNA (0.54) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL31188768 | 0.86 | LMNA (0.54) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL9730053 | 0.85 | ALDH1A1 (0.47) | LMNAALDH1A1MAPTKDM4ECYP3A4 | |
| SCHEMBL2373598 | 0.85 | ALDH1A1 (0.57) | LMNAALDH1A1MAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102344382-A | Method for preparing 2,5-dimethoxy-4-chloroaniline by hydrogenation reduction | HEBEI HUA CHEM DYE CHEMICAL CO LTD | 2012-02-08 | — | — | CN | claimed |
| CN-102344380-A | Method for preparing 2,5-dimethoxy-4-chloroaniline by using liquid-phase catalytic hydrogenation method | JIANGSU LIDANING CHEMICAL CO LTD | 2012-02-08 | — | — | CN | claimed |
| US-20220162172-A1 | QUINAZOLINONE COMPOUNDS | CEREPEUT, INC. | 2022-05-26 | — | — | US | disclosed |
| CN-107325002-B | Method for synthesizing aryl halide by taking aryl carboxylic acid as raw material | 南昌大学 | 2020-03-27 | — | — | CN | disclosed |
| CN-107325002-A | A kind of synthetic method using aryl carboxylic acid as the aryl halide of raw material | 南昌大学 | 2017-11-07 | — | — | CN | disclosed |
| CN-105949069-A | Method for continuous hydrogenation production of 4-chloro-2,5-dimethoxyaniline | 济南和润化工科技有限公司 | 2016-09-21 | — | — | CN | disclosed |
| CN-205556513-U | Continuous hydrogenation ware of organic intermediate | 彩客科技（北京）有限公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-105566112-A | Continuous hydrogenation reaction method of organic intermediates and reactor thereof | TSAKER TECH (BEIJING) CO LTD | 2016-05-11 | — | — | CN | disclosed |
| US-8999988-B2 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-04-07 | — | — | US | disclosed |
| US-8999988-B2 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-04-07 | — | — | US | disclosed |
| CN-103265441-B | Preparation method of 2,5-dimethoxyl-4-chloroaniline | XIANGSHUI HENRYDA TECH CHEMICAL CO LTD | 2014-06-11 | — | — | CN | disclosed |
| WO-1997044334-A2 | NOVEL PIPERAZINE OR HOMOPIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THEIR PREPARATION | EGIS Gyógyszergyár Rt. (HU) | 1997-11-27 | — | — | WO | disclosed |
| EP-0122533-B1 | COLOUR-PHOTOGRAPHIC RECORDING MATERIAL CONTAINING A COLOUR COUPLER | Agfa-Gevaert AG (DE) | 1989-01-25 | — | — | EP | disclosed |
| US-4714700-A | TRANQUILIZERS, ANXIOLYTIC AGENTS | CHOAY S.A. (FR) | 1987-12-22 | — | — | US | disclosed |
| US-4618459-A | INTERMEDIATES FOR BENZENESULFONAMIDE DERIVATIVES; ANTIDEPRESSANTS | CHOAY S.A. (FR) | 1986-10-21 | — | — | US | disclosed |
| US-4529691-A | Non-diffusible yellow coupler | AGFA-GEVAERT AG (DE) | 1985-07-16 | — | — | US | disclosed |
| EP-0122533-A2 | Colour-photographic recording material containing a colour coupler | Agfa-Gevaert AG (DE) | 1984-10-24 | — | — | EP | disclosed |
| US-4457875-A | ANTIDEPRESSANTS, TRANQUILIZERS | CHOAY S.A. (FR) | 1984-07-03 | — | — | US | disclosed |
| EP-0039440-B1 | MEDICINES CONTAINING SUBSTITUTED BENZOTHIAZOL-2-(3H)-ONES | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0039440-A1 | Medicines containing substituted benzothiazol-2-(3H)-ones | Dr. Karl Thomae GmbH (DE) | 1981-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220162172-A1 | QUINAZOLINONE COMPOUNDS | NDUFAB1, NDUFV1, NDUFV2 | LMNA 927/4885ALDH1A1 1693/4885MAPT 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.