SCHEMBL8536622

SCHEMBL8536622

COc1cc(Cl)c([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 1/20 0.51
LMNA P02545 3/20 0.50
ALDH1A1 P00352 6/20 0.48
TDP1 Q9NUW8 2/20 0.48
MAPT P10636 3/20 0.47
CYP3A4 P08684 2/20 0.47
KDM4E B2RXH2 1/20 0.47
ALOX15 P16050 1/20 0.47
PRKDC P78527 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MAPK1 P28482 2/20 0.46
TSHR P16473 1/20 0.46
RAF1 P04049 1/20 0.45
HPGD P15428 1/20 0.45
GFER P55789 1/20 0.45
PAX8 Q06710 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30435204 1.00 MERTK (0.51) MERTKLMNAALDH1A1TDP1MAPT
SCHEMBL10983166 0.90 LMNA (0.51) MERTKLMNAALDH1A1TDP1MAPT
SCHEMBL3103536 0.90 LMNA (0.59) MERTKLMNAALDH1A1TDP1MAPT
SCHEMBL310130 0.89 LMNA (0.54) LMNAALDH1A1TDP1MAPTCYP3A4
SCHEMBL31188768 0.89 LMNA (0.54) LMNAALDH1A1TDP1MAPTCYP3A4
SCHEMBL2874199 0.89 LMNA (0.50) MERTKLMNAALDH1A1TDP1MAPT
SCHEMBL6370055 0.86 ALDH1A1 (0.57) LMNAALDH1A1TDP1MAPTCYP3A4
SCHEMBL4132806 0.85 LMNA (0.48) MERTKLMNAALDH1A1TDP1MAPT
Methyl Alcohol SCHEMBL28097248 0.85 LMNA (0.55) LMNAALDH1A1TDP1MAPTCYP3A4
SCHEMBL3122999 0.85 RAB9A (0.50) LMNAALDH1A1TDP1MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116410114-B 4-nitrobenzene sulfur chlorine amino protecting group and preparation method thereof 南开大学 2024-02-27 CN claimed
CN-116410114-A 4-nitrobenzene sulfur chlorine amino protecting group and preparation method thereof 南开大学 2023-07-11 CN claimed
CN-116410114-B 4-nitrobenzene sulfur chlorine amino protecting group and preparation method thereof 南开大学 2024-02-27 CN disclosed
CN-116410114-A 4-nitrobenzene sulfur chlorine amino protecting group and preparation method thereof 南开大学 2023-07-11 CN disclosed
EP-3081581-B1 DIAZORESIN, PHOTORESIST COMPOSITION AND PREPARATION METHOD OF PHOTORESIST COMPOSITION BOE TECHNOLOGY GROUP CO LTD (CN) 2019-08-07 EP disclosed
US-10303053-B2 Diazo-resin, photoresist composition and method of preparing same BOE TECHNOLOGY GROUP CO., LTD. (CN) 2019-05-28 US disclosed
US-20160334704-A1 DIAZO-RESIN, PHOTORESIST COMPOSITION AND METHOD OF PREPARING SAME BOE TECHNOLOGY GROUP CO., LTD. (CN) 2016-11-17 US disclosed
EP-3081581-A1 DIAZORESIN, PHOTORESIST COMPOSITION AND PREPARATION METHOD OF PHOTORESIST COMPOSITION BOE Technology Group Co., Ltd. (CN) 2016-10-19 EP disclosed
EP-0591059-B1 Use of sulfur-containing metaphenylenediamines for dyeing keratinic fibers and new sulfur-containing metaphenylenediamines OREAL (FR) 1998-04-15 EP disclosed
US-5534036-A Keratinous fiber dyeing methods and compositions which contain sulfated methaphenylenediamine couplers in combination with oxidation dye precursors L'OREAL (FR) 1996-07-09 US disclosed
EP-0591059-A1 Use of sulfur-containing metaphenylenediamines for dyeing keratinic fibers and new sulfur-containing metaphenylenediamines L'OREAL (FR) 1994-04-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10303053-B2 Diazo-resin, photoresist composition and method of preparing same LCP1, CAD, CDH1 MERTK 1061/4885LMNA 1191/4885ALDH1A1 4410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.