Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057868 | 0.96 | SIGMAR1 (0.43) | SIGMAR1BRD4PDE3BPDE3ASHMT1 | |
| SCHEMBL31057873 | 0.95 | SIGMAR1 (0.43) | SIGMAR1BRD4PDE3BPDE3ASUV39H2 | |
| SCHEMBL31057939 | 0.92 | SIGMAR1 (0.42) | SIGMAR1BRD4SHMT1ACKR3GAA | |
| SCHEMBL31057975 | 0.87 | SHMT1 (0.42) | SIGMAR1BRD4SHMT1LMNACASP1 | |
| SCHEMBL31057641 | 0.86 | GPR4 (0.45) | SIGMAR1SHMT1ACKR3DRD3 | |
| SCHEMBL31057929 | 0.83 | SHMT1 (0.44) | SIGMAR1SHMT1ACKR3 | |
| SCHEMBL31057864 | 0.77 | ACKR3 (0.49) | PDE3BPDE3ASUV39H2SHMT1ACKR3 | |
| SCHEMBL31578853 | 0.75 | ACKR3 (0.48) | ACKR3MAPT | |
| SCHEMBL31578793 | 0.67 | ACKR3 (0.48) | ACKR3 | |
| SCHEMBL20241695 | 0.67 | SHMT1 (0.62) | SHMT1GAAMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |