Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 9/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057939 | 0.95 | SIGMAR1 (0.42) | SHMT1SHMT2SIGMAR1DRD3FNTA | |
| SCHEMBL31057873 | 0.93 | SIGMAR1 (0.43) | SHMT1SHMT2SIGMAR1DRD3MEN1 | |
| SCHEMBL31057929 | 0.92 | SHMT1 (0.44) | SHMT1SHMT2SIGMAR1LTA4H | |
| SCHEMBL31057868 | 0.88 | SIGMAR1 (0.43) | SHMT1SIGMAR1DRD3MEN1ALDH1A1 | |
| SCHEMBL31057883 | 0.87 | SIGMAR1 (0.45) | SHMT1SIGMAR1DRD3TSHRSMN1; SMN2 | |
| SCHEMBL31057641 | 0.84 | GPR4 (0.45) | SHMT1SIGMAR1DRD3ALDH1A1 | |
| SCHEMBL31057864 | 0.78 | ACKR3 (0.49) | SHMT1SHMT2DRD3ALDH1A1RET | |
| SCHEMBL31578816 | 0.73 | ACKR3 (0.47) | SHMT1SHMT2 | |
| SCHEMBL31578853 | 0.72 | ACKR3 (0.48) | ALDH1A1 | |
| SCHEMBL31057961 | 0.70 | SHMT1 (0.68) | SHMT1SHMT2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |