Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312756 | 0.94 | HDAC1 (0.47) | HDAC1HDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL7947091 | 0.88 | ALDH1A1 (0.51) | HDAC1HDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL3120950 | 0.84 | ALDH1A1 (0.40) | ALDH1A1KMT2ARAB9ANPC1TDO2 | |
| SCHEMBL4304078 | 0.81 | MAPK14 (0.43) | HDAC1HDAC6ALDH1A1KMT2AMAPT | |
| SCHEMBL7985731 | 0.81 | MAPT (0.55) | HDAC1HDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL4312470 | 0.81 | ALDH1A1 (0.42) | HDAC1HDAC6ALDH1A1KMT2AMAPK1 | |
| SCHEMBL4308534 | 0.80 | ADRA1D (0.43) | ALDH1A1 | |
| SCHEMBL4313368 | 0.80 | ALDH1A1 (0.43) | HDAC1HDAC6ALDH1A1RAB9ATDO2 | |
| SCHEMBL4310271 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL4305038 | 0.78 | MAPT (0.51) | HDAC1HDAC6ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |