Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089520 | 0.72 | NPSR1 (0.51) | NPSR1LMNAL3MBTL1HTTGAA | |
| SCHEMBL9641039 | 0.69 | LMNA (0.49) | NPSR1LMNAL3MBTL1HTTGAA | |
| SCHEMBL14938940 | 0.69 | NPSR1 (0.49) | NPSR1LMNAL3MBTL1HTTGAA | |
| SCHEMBL9488212 | 0.66 | L3MBTL1 (0.49) | NPSR1LMNAL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL28151824 | 0.66 | L3MBTL1 (0.49) | NPSR1LMNAL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL11258854 | 0.65 | ALDH1A1 (0.44) | NPSR1LMNAL3MBTL1HTTGAA | |
| SCHEMBL4459204 | 0.64 | NPSR1 (0.50) | NPSR1LMNAL3MBTL1HTTKMT2A | |
| SCHEMBL31599138 | 0.64 | SIGMAR1 (0.51) | NPSR1LMNAL3MBTL1HTTMAOA | |
| SCHEMBL11500029 | 0.64 | SIGMAR1 (0.51) | NPSR1LMNAL3MBTL1HTTMAOA | |
| SCHEMBL4463201 | 0.64 | NPSR1 (0.50) | NPSR1LMNAL3MBTL1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423359-B1 | C2-DISUBSTITUTED INDANE-1-ONES AND THEIR DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-07-14 | — | — | EP | disclosed |
| US-7081467-B2 | C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-25 | — | — | US | disclosed |
| EP-1423359-A1 | C2-DISUBSTITUTED INDANE-1-ONES AND THEIR DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2004-06-02 | — | — | EP | disclosed |
| US-20030153609-A1 | C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals | AVENTIS PHARMA DUTSCHLAN GMBH. | 2003-08-14 | — | — | US | disclosed |
| WO-2003020697-A1 | C2-DISUBSTITUTED INDANE-1-ONES AND THEIR DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153609-A1 | C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals | GPR119, INSR, IRS1 | NPSR1 840/4885LMNA 2451/4885L3MBTL1 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.