Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31363665 | 0.82 | GPR119 (0.33) | GPR119SMN1; SMN2PDK1PDK2PDK3 | |
| SCHEMBL23144207 | 0.81 | HRH4 (0.43) | GPR119SMN1; SMN2PDK1PDK2PDK3 | |
| SCHEMBL29811800 | 0.81 | HRH4 (0.43) | GPR119SMN1; SMN2PDK1PDK2PDK3 | |
| SCHEMBL23144238 | 0.79 | KCNH2 (0.39) | GPR119SMN1; SMN2PDK1PDK2PDK3 | |
| SCHEMBL25033220 | 0.77 | GPR119 (0.33) | GPR119SMN1; SMN2LMNANR1H2NR1H3 | |
| SCHEMBL31270355 | 0.77 | GPR119 (0.33) | GPR119SMN1; SMN2LMNANR1H2NR1H3 | |
| SCHEMBL31363483 | 0.74 | PDK1 (0.43) | GPR119SMN1; SMN2PDK1PDK2PDK3 | |
| SCHEMBL23155514 | 0.72 | KDM4E (0.39) | GPR119SMN1; SMN2 | |
| SCHEMBL31401161 | 0.69 | PKM (0.40) | SMN1; SMN2CA1CA2CA9CA4 | |
| SCHEMBL24852792 | 0.67 | KEAP1 (0.46) | SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025059074-A1 | BICYCLIC COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2025-03-20 | — | — | WO | disclosed |