Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfanilamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.61 |
| ▸ | CA9 | Q16790 | 13/20 | 0.61 |
| ▸ | CA12 | O43570 | 11/20 | 0.61 |
| ▸ | CA1 | P00915 | 11/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.61 |
| ▸ | CA7 | P43166 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | CA4 | P22748 | 2/20 | 0.61 |
| ▸ | CA6 | P23280 | 2/20 | 0.61 |
| ▸ | CA5A | P35218 | 2/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.61 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminothiazole SCHEMBL8170653 | 0.82 | ALDH1A1 (0.79) | TSHRTDP1CYP2C9ALDH1A1LMNA | |
| Sulfanilamide SCHEMBL27764298 | 0.80 | CA2 (0.94) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL22501553 | 0.80 | CA2 (0.94) | CA2CA9CA12CA1CA14 | |
| Sulfathiazole SCHEMBL28264889 | 0.80 | ALDH1A1 (0.89) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL2798899 | 0.78 | CA2 (1.00) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL30659052 | 0.78 | CA2 (1.00) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL740 | 0.78 | CA2 (1.00) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL31544839 | 0.78 | CA2 (1.00) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL28956158 | 0.76 | CA2 (0.85) | CA2CA9CA12CA1CA14 | |
| Sulfanilamide SCHEMBL5894222 | 0.76 | CA2 (0.94) | CA2CA9CA12CA1CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018095576-A1 | TOPICAL PHARMACEUTICAL FORMULATION COMPRISING N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)-PHENYL]-ACETAMIDE | AICURIS ANTI-INFECTIVE CURES GMBH (DE) | 2018-05-31 | — | — | WO | disclosed |
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2119719-A1 | THIAZEPINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | HSD11B1, HSD17B1, HSD3B1 | CA2 1079/4885CA9 895/4885CA12 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.