Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.51 |
| ▸ | ACE | P12821 | 6/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966188 | 1.00 | LMNA (0.55) | LMNAHSD17B10CYP2C19FKBP1AACE | |
| SCHEMBL5966112 | 0.95 | FKBP1A (0.57) | LMNAHSD17B10CYP2C19FKBP1A | |
| SCHEMBL5966063 | 0.95 | FKBP1A (0.57) | LMNAHSD17B10CYP2C19FKBP1A | |
| SCHEMBL5966065 | 0.95 | FKBP1A (0.57) | LMNAHSD17B10CYP2C19FKBP1A | |
| SCHEMBL27714243 | 0.93 | FKBP1A (0.58) | LMNAHSD17B10CYP2C19FKBP1A | |
| SCHEMBL7255035 | 0.89 | FKBP1A (0.43) | LMNAHSD17B10CYP2C19FKBP1AACE | |
| SCHEMBL3330557 | 0.83 | LMNA (0.57) | LMNAHSD17B10CYP2C19FKBP1AACE | |
| Gpi-1485 SCHEMBL3568704 | 0.83 | FKBP1A (0.66) | LMNAHSD17B10CYP2C19FKBP1A | |
| Gpi-1485 SCHEMBL2006950 | 0.83 | FKBP1A (0.66) | LMNAHSD17B10CYP2C19FKBP1A | |
| SCHEMBL2636385 | 0.81 | LMNA (0.68) | LMNAHSD17B10CYP2C19ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282510-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2007-10-16 | — | — | US | claimed |
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD NIL HOLDINGS, INC. | 2005-12-08 | — | — | US | claimed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | claimed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | claimed |
| EP-1404325-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-07 | — | — | EP | claimed |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 2004-03-11 | — | — | US | claimed |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-10-30 | — | — | US | claimed |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | GLIAMED, INC. | 2002-12-26 | — | — | US | claimed |
| WO-2002096420-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | claimed |
| US-6218423-B1 | ADMINISTERING PYRROLIDINE DERIVATIVE FOR THERAPY OF NERVE-RELATED VISION DISORDER, IMPROVING VISION, TREATING MEMORY IMPAIRMENT, OR ENHANCING MEMORY PERFORMANCE IN ANIMAL | GPI NIL HOLDINGS, INC. | 2001-04-17 | — | — | US | claimed |
| US-6177455-B1 | ADMINISTERING A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | GPI NIL HOLDINGS, INC. | 2001-01-23 | — | — | US | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| US-5945441-A | ADMINISTERING TO PROMOTE HAIR GERMINATION | GPI NIL HOLDINGS, INC. (US) | 1999-08-31 | — | — | US | claimed |
| US-5859031-A | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1999-01-12 | — | — | US | claimed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | claimed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | claimed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | LMNA 956/4885HSD17B10 1997/4885CYP2C19 4807/4885 |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NGF, BDNF, GAP43 | LMNA 1638/4885HSD17B10 951/4885CYP2C19 3931/4885 |
| US-20040049046-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP14, PREP | LMNA 4805/4885HSD17B10 2163/4885CYP2C19 3078/4885 |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP1A, PREP | LMNA 4762/4885HSD17B10 1755/4885CYP2C19 2787/4885 |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | LMNA 4536/4885HSD17B10 574/4885CYP2C19 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.