Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5086079 | 0.85 | KDM4E (0.37) | LMNAALOX15HSD17B10CAMK2AKMT2A | |
| SCHEMBL2495440 | 0.85 | CA12 (0.44) | LMNATSHRPMP22ALOX15HSD17B10 | |
| SCHEMBL819365 | 0.85 | CAMK2A (0.36) | ALOX15HSD17B10CAMK2A | |
| SCHEMBL33625 | 0.84 | SLC22A6 (0.61) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL431916 | 0.84 | LMNA (0.61) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL636292 | 0.83 | PAOX (0.47) | TSHRALOX15S1PR1S1PR3S1PR2 | |
| SCHEMBL246135 | 0.83 | ALOX15 (0.45) | TSHRALOX15S1PR1S1PR3S1PR2 | |
| SCHEMBL112741 | 0.83 | LMNA (0.59) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL7779000 | 0.83 | ALOX15 (0.34) | ALOX15HSD17B10 | |
| SCHEMBL4276362 | 0.82 | ALDH1A1 (0.50) | TSHRALOX15S1PR1S1PR3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751405-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | claimed |
| EP-0751404-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | claimed |
| EP-0751407-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | claimed |
| US-5391669-A | Lens formed of water swellable crosslinked polymer containing polymer containing cationic-aninoic pair of unsaturated monomers and nonionic monomers | HYDRON LIMITED (GB) | 1995-02-21 | — | — | US | claimed |
| EP-0563299-A4 | BALANCED CHARGE POLYMER AND HYDROPHILIC CONTACT LENS MANUFACTURED THEREFROM | CESKOSLOVENSKA AKADEMIE VED (CS) | 1994-07-20 | — | — | EP | claimed |
| US-5270415-A | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | ALLERGAN INC. (US) | 1993-12-14 | — | — | US | claimed |
| EP-0563299-A1 | BALANCED CHARGE POLYMER AND HYDROPHILIC CONTACT LENS MANUFACTURED THEREFROM | Hydron Limited (GB) | 1993-10-06 | — | — | EP | claimed |
| WO-1992011301-A1 | BALANCED CHARGE POLYMER AND HYDROPHILIC CONTACT LENS MANUFACTURED THEREFROM | ALLERGAN, INC. (US) | 1992-07-09 | — | — | WO | claimed |
| US-20100069544-A1 | HYDROGEL CONTACT LENS COMPRISING A POLYMER COMPRISING A CARBOXY BETAINE ESTER MONOMER | PROCORNEA HOLDING B.V. | 2010-03-18 | — | — | US | disclosed |
| EP-2087397-A1 | HYDROGEL CONTACT LENS COMPRISING A POLYMER COMPRISING A CARBOXY BETAINE ESTER MONOMER | Procornea Holding B.V. (NL) | 2009-08-12 | — | — | EP | disclosed |
| EP-1286823-B1 | OPHTHALMIC LENSES AND COMPOSITIONS, AND METHODS FOR PRODUCING SAME | COOPERVISION INT HOLDING CO LP (BB) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008066381-A1 | HYDROGEL CONTACT LENS COMPRISING A POLYMER COMPRISING A CARBOXY BETAINE ESTER MONOMER | PROCORNEA HOLDING B.V. (NL) | 2008-06-05 | — | — | WO | disclosed |
| US-7262232-B2 | Ophthalmic lenses and compositions and methods for producing same | COOPERVISION, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-6992118-B2 | Ophthalmic lenses and compositions and methods for producing same | COOPER VISION INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-0751405-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | disclosed |
| EP-0751406-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | disclosed |
| EP-0751407-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | disclosed |
| EP-0751404-A2 | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | Hydron Limited (GB) | 1997-01-02 | — | — | EP | disclosed |
| US-5391669-A | Lens formed of water swellable crosslinked polymer containing polymer containing cationic-aninoic pair of unsaturated monomers and nonionic monomers | HYDRON LIMITED (GB) | 1995-02-21 | — | — | US | disclosed |
| US-5270415-A | Balanced charge polymer and hydrophilic contact lens manufactured therefrom | ALLERGAN INC. (US) | 1993-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069544-A1 | HYDROGEL CONTACT LENS COMPRISING A POLYMER COMPRISING A CARBOXY BETAINE ESTER MONOMER | CRYAA, CRYZ, CRYAB | LMNA 1846/4885SLC22A6 1329/4885TSHR 2672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.