Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 2/20 | 0.44 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.44 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.41 |
| ▸ | RELA | Q04206 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661587 | 0.88 | SMN1; SMN2 (0.56) | CHUKTXNRD1NOX4SMN1; SMN2ALDH1A1 | |
| SCHEMBL31661630 | 0.81 | PTGS2 (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL31661659 | 0.80 | LMNA (0.55) | SMN1; SMN2ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL31661641 | 0.78 | S1PR1 (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL31661762 | 0.76 | NR1H4 (0.50) | SMN1; SMN2ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL31661744 | 0.76 | NR1H4 (0.50) | SMN1; SMN2ALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL31661780 | 0.76 | NPC1 (0.52) | SMN1; SMN2ALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL31661764 | 0.76 | RAB9A (0.43) | SMN1; SMN2KDM4EMAPK1L3MBTL1TP53 | |
| SCHEMBL31661677 | 0.75 | USP1 (0.52) | CHUKTXNRD1NOX4SMN1; SMN2MAPK1 | |
| SCHEMBL31661691 | 0.75 | S1PR1 (0.38) | CHUKTXNRD1NOX4SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025151705-A1 | NOVEL INHIBITORS OF DNA DAMAGE REPAIR PATHWAY | VRISE THERAPEUTICS, INC. (US) | 2025-07-17 | — | — | WO | claimed |
| WO-2025151705-A1 | NOVEL INHIBITORS OF DNA DAMAGE REPAIR PATHWAY | VRISE THERAPEUTICS, INC. (US) | 2025-07-17 | — | — | WO | disclosed |