SCHEMBL31703486

SCHEMBL31703486

O=C(CN1CC[C@H](n2cncn2)C1)Nc1ccc(Oc2cccc(Cl)c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 1/20 0.46
▸ ALDH1A1 P00352 4/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ GLA P06280 1/20 0.45
▸ HPGD P15428 4/20 0.44
▸ GAA P10253 2/20 0.44
▸ LMNA P02545 2/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ MAPT P10636 2/20 0.44
▸ TSHR P16473 1/20 0.44
▸ FNTA P49354 1/20 0.44
▸ FNTB P49356 1/20 0.44
▸ FAAH O00519 2/20 0.42
▸ LTA4H P09960 1/20 0.42
▸ ALOX15 P16050 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31703966 1.00 IDO1 (0.46) IDO1ALDH1A1MEN1KMT2AGLA
SCHEMBL31703598 0.91 ALDH1A1 (0.47) IDO1ALDH1A1MEN1KMT2AGLA
SCHEMBL31703383 0.90 MTNR1B (0.50) ALDH1A1MEN1KMT2AGLAGAA
SCHEMBL31703747 0.88 POLB (0.48) MEN1KMT2AFAAH
SCHEMBL31703416 0.83 TACR2 (0.41) FAAH
SCHEMBL31703740 0.83 TACR2 (0.41) FAAH
SCHEMBL31703485 0.83 IDO1 (0.45) IDO1ALDH1A1MEN1KMT2AGLA
SCHEMBL31703579 0.80 MEN1 (0.47) ALDH1A1MEN1KMT2AGAALMNA
SCHEMBL31703444 0.80 TACR2 (0.40) FAAH
SCHEMBL31703921 0.78 LTA4H (0.54) IDO1ALDH1A1MEN1KMT2AGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025217513-A1 ACTIVATION OF PLCG2 AS A THERAPEUTIC STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE THE TRUSTEES OF INDIANA UNIVERSITY (US) 2025-10-16 — — WO claimed
WO-2025217513-A1 ACTIVATION OF PLCG2 AS A THERAPEUTIC STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE THE TRUSTEES OF INDIANA UNIVERSITY (US) 2025-10-16 — — WO disclosed
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