Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 8/20 | 0.72 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.72 |
| ▸ | HNF4A | P41235 | 2/20 | 0.72 |
| ▸ | DHFR | P00374 | 1/20 | 0.72 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23143193 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL330602 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL29759663 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL9273036 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL9652822 | 0.82 | ACMSD (0.96) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL2070297 | 0.81 | MCL1 (0.72) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL5308985 | 0.81 | ACMSD (0.72) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| Zinc Ion SCHEMBL9652815 | 0.79 | ACMSD (0.70) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL8054721 | 0.79 | GSTA1 (0.74) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL10621564 | 0.79 | GSTA1 (0.74) | ACMSDMCL1HNF4ADHFRGSTA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1872846-B | Method of preparing 2-benzothiazepines derivative | UBE INDUSTRIES | 2010-06-16 | — | — | CN | disclosed |
| US-7671195-B2 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2010-03-02 | — | — | US | disclosed |
| CN-100577653-C | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES | 2010-01-06 | — | — | CN | disclosed |
| CN-101389615-A | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LTD UBE IND (GB) | 2009-03-18 | — | — | CN | disclosed |
| EP-1996568-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2008-12-03 | — | — | EP | disclosed |
| US-7314930-B2 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| WO-2007102352-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2007-09-13 | — | — | WO | disclosed |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| CN-1872846-A | Method of preparing 2-benzothiazepines derivative | UBE INDUSTRIES (JP) | 2006-12-06 | — | — | CN | disclosed |
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-08-03 | — | — | US | disclosed |
| CN-1810792-A | Process for preparing dibenzothiazepine * derivatives | UBE INDUSTRIES (JP) | 2006-08-02 | — | — | CN | disclosed |
| US-7045621-B1 | Process for producing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-05-16 | — | — | US | disclosed |
| CN-1247556-C | Process for preparing dibenzothiazepine * derivatives | UBE INDUSTRIES (JP) | 2006-03-29 | — | — | CN | disclosed |
| CN-1367782-A | Process for preparing dibenzothiazepine * derivatives | UBE INDUSTRIES (JP) | 2002-09-04 | — | — | CN | disclosed |
| EP-1201663-A1 | PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES | Ube Industries, Ltd. (JP) | 2002-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | TPMT, BBOX1, NISCH | ACMSD 128/4885MCL1 1327/4885HNF4A 2148/4885 |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | TST, ADH1C, ADH5 | ACMSD 4/4885MCL1 2602/4885HNF4A 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.