Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | LTA4H | P09960 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3210452 | 0.99 | ALDH1A1 (0.70) | ALDH1A1MAPTRAB9AHTTLMNA | |
| SCHEMBL5660090 | 0.86 | ALDH1A1 (0.68) | ALDH1A1MAPTLMNALTA4HSMN1; SMN2 | |
| SCHEMBL5337343 | 0.85 | ALDH1A1 (0.80) | ALDH1A1MAPTRAB9AHTTLMNA | |
| SCHEMBL3224693 | 0.85 | NPC1 (0.63) | ALDH1A1RAB9AHTTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3211216 | 0.84 | NPC1 (0.62) | ALDH1A1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL5659690 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTRAB9AHTTLMNA | |
| SCHEMBL5659280 | 0.81 | ALDH1A1 (0.76) | ALDH1A1MAPTRAB9AHTTLMNA | |
| SCHEMBL21067416 | 0.78 | LTA4H (1.00) | ALDH1A1RAB9ALTA4HSMN1; SMN2CYP1A2 | |
| SCHEMBL4576852 | 0.78 | SMN1; SMN2 (0.72) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL15210943 | 0.78 | NPC1 (0.71) | ALDH1A1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8519139-B2 | Indazolamides with analgesic activity | Aziende Chimeche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) | 2013-08-27 | — | — | US | disclosed |
| EP-1594859-B1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | ACRAF (IT) | 2010-06-23 | — | — | EP | disclosed |
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A. (IT) | 2010-02-25 | — | — | US | disclosed |
| US-7632849-B2 | N3-((1-(2-Oxo-2-(phenylamino)ethyl)-4-piperidyl)methyl)- 1-(1-methylethyl)-1H-indazole-3-carboxamide; antiarthritic agents; rheumatic diseases; osteoarthritis; fibromyaleia;anticarcinogenic agents, pain; neuropathic pain; immunoincompetance; trauma; antiischemic agents; multiple sclerosis | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-15 | — | — | US | disclosed |
| US-20060052417-A1 | Indazolamides with analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2006-03-09 | — | — | US | disclosed |
| EP-1594859-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074275-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | TRPV1, CA2, TRPV2 | ALDH1A1 571/4885MAPT 3032/4885RAB9A 2858/4885 |
| US-20060052417-A1 | Indazolamides with analgesic activity | P2RX7, P2RX3, P2RX1 | ALDH1A1 870/4885MAPT 3312/4885RAB9A 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.