Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457210 | 0.98 | KDM4E (0.45) | THRANCF1KDM4ERECQLL3MBTL1 | |
| SCHEMBL919504 | 0.90 | ALDH1A1 (0.43) | THRAKDM4EL3MBTL1NQO1ALDH1A1 | |
| SCHEMBL920395 | 0.90 | SMN1; SMN2 (0.42) | THRANCF1KDM4ENQO1CYP2D6 | |
| SCHEMBL921599 | 0.88 | NR5A1 (0.43) | KDM4ENQO1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL919784 | 0.88 | NR5A1 (0.43) | KDM4ENQO1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL920256 | 0.88 | NR5A1 (0.43) | KDM4ENQO1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7928494 | 0.86 | LMNA (0.41) | KDM4ERECQLL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL4061378 | 0.84 | NQO1 (0.57) | THRANCF1KDM4ERECQLL3MBTL1 | |
| SCHEMBL10785918 | 0.84 | KCNA3 (0.43) | KDM4ERECQLNQO1TDP1ALDH1A1 | |
| SCHEMBL2499531 | 0.83 | NQO1 (0.44) | KDM4ERECQLNQO1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102234287-B | Nitro glyoxaline compound, Preparation Method And The Use | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2015-08-05 | — | — | CN | claimed |
| EP-2573090-B1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-12-10 | — | — | EP | claimed |
| US-8563547-B2 | (6,7-dihydro-2-nitro-5H-imidazol[2,1-b][1,3]oxazin-6-yl) amide compounds, preparation methods and uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2013-10-22 | — | — | US | claimed |
| US-20130143864-A1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | NANJING CHANGAO PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2013-06-06 | — | — | US | claimed |
| EP-2573090-A1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd (CN) | 2013-03-27 | — | — | EP | claimed |
| CN-102234287-A | Nitro imidazole compound, its preparation method and application | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD | 2011-11-09 | — | — | CN | claimed |
| US-20100317653-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2010-12-16 | — | — | US | claimed |
| US-7759349-B2 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2010-07-20 | — | — | US | claimed |
| US-20080312271-A1 | AZABENZIMIDAZOLYL COMPOUNDS | PFIZER INC. | 2008-12-18 | — | — | US | claimed |
| US-20080280933-A1 | BENZIMIDAZOLYL COMPOUNDS | EFREMOV IVAN | 2008-11-13 | — | — | US | claimed |
| EP-0991620-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 2000-04-12 | — | — | EP | claimed |
| US-6022898-A | ALPHA-SULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACIDS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-02-08 | — | — | US | claimed |
| EP-0766665-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-07-28 | — | — | EP | claimed |
| WO-1998057933-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-12-23 | — | — | WO | claimed |
| EP-0766665-A2 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-04-09 | — | — | EP | claimed |
| EP-0766664-A2 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-04-09 | — | — | EP | claimed |
| WO-1995035276-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| WO-1995035275-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| EP-0254856-B1 | PYRIDINETHANOL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-04 | — | — | EP | claimed |
| US-4988714-A | Drugs for treatment of obesity and diabetics, increases protein breakdown, for fattening animals | HOFFMANN-LA ROCHE INC. (US) | 1991-01-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317653-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | DGAT1, DGAT2, GPR119 | THRA 1633/4885NCF1 3702/4885KDM4E 3511/4885 |
| US-20080280933-A1 | BENZIMIDAZOLYL COMPOUNDS | PAICS, TMBIM6, ABCG2 | THRA 4516/4885NCF1 3079/4885KDM4E 2254/4885 |
| US-20130143864-A1 | (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | MT-ND6, SLC11A2, NDUFB7 | THRA 3344/4885NCF1 808/4885KDM4E 3845/4885 |
| US-20080312271-A1 | AZABENZIMIDAZOLYL COMPOUNDS | AZI2, PAICS, UGT2B7 | THRA 4207/4885NCF1 2323/4885KDM4E 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.