SCHEMBL3223714

SCHEMBL3223714

COc1ccc(O)cc1Cc1ccc(C)nc1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 7/20 0.46
CYP19A1 P11511 1/20 0.45
DHFR P00374 1/20 0.40
HTT P42858 1/20 0.40
ELANE P08246 1/20 0.40
CTSG P08311 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
NPC1 O15118 1/20 0.39
POLB P06746 1/20 0.39
RAB9A P51151 1/20 0.39
CSF1R P07333 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7284246 0.86 CYP19A1 (0.45) PDE10ACYP19A1DHFRHTTELANE
SCHEMBL3212327 0.82 FTO (0.47) PDE10ACYP19A1DHFRHTTELANE
SCHEMBL11885456 0.79 LTA4H (0.47) PDE10A
SCHEMBL7283988 0.77 CALM1 (0.50) CYP19A1SMN1; SMN2NPC1RAB9A
SCHEMBL5801725 0.75 ALOX5 (0.56) CYP19A1ELANECTSG
SCHEMBL8732819 0.74 ALDH1A1 (0.45) CYP19A1POLBRAB9A
SCHEMBL29066049 0.74 TUBB4A (0.59) DHFR
SCHEMBL7283400 0.71 IDO1 (0.42) PDE10ADHFRCSF1R
SCHEMBL23643012 0.70 NPC1 (0.56) SMN1; SMN2NPC1POLBRAB9ACSF1R
SCHEMBL5884678 0.69 DHFR (0.64) DHFRHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US claimed
EP-1404413-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2004-04-07 EP claimed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP claimed
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
WO-2002089917-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2002-11-14 WO claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
US-20100047332-A1 Treatments for burns using thyroid hormone compound in a human KOO, CATHERINE, DR 2010-02-25 US disclosed
EP-0831769-B2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS LAVIN DR THOMAS N (US) 2008-07-23 EP disclosed
WO-2007002036-A1 TYROID HORMONE IN BURN AND ADIPOSE DEPOSITES LAVIN THOMAS (US) 2007-01-04 WO disclosed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO disclosed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP disclosed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO disclosed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO disclosed