Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | RAD52 | P43351 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224693 | 0.83 | NPC1 (0.63) | ALDH1A1LMNAKDM4ERAB9AL3MBTL1 | |
| SCHEMBL27560625 | 0.82 | MAPT (0.48) | ALDH1A1MAPTLMNATDP1MAPK1 | |
| Hydrochloric Acid SCHEMBL3211216 | 0.82 | NPC1 (0.62) | ALDH1A1LMNAKDM4ERAB9AL3MBTL1 | |
| SCHEMBL4185215 | 0.79 | ALDH1A1 (0.71) | ALDH1A1MAPTLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3223889 | 0.79 | LMNA (0.70) | ALDH1A1MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL5660090 | 0.78 | ALDH1A1 (0.68) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL3211268 | 0.75 | ALDH1A1 (0.69) | ALDH1A1MAPTLMNAMAPK1RAB9A | |
| Hydrochloric Acid SCHEMBL3210452 | 0.74 | ALDH1A1 (0.70) | ALDH1A1MAPTLMNAMAPK1RAB9A | |
| Hydrochloric Acid SCHEMBL3206106 | 0.73 | ALDH1A1 (0.61) | ALDH1A1LMNARAB9ACYP1A2CYP3A4 | |
| SCHEMBL13118219 | 0.72 | KCNT1 (0.76) | ALDH1A1MAPTTDP1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8519139-B2 | Indazolamides with analgesic activity | Aziende Chimeche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) | 2013-08-27 | — | — | US | disclosed |
| CN-101139341-B | Indazolamides with analgesic activity | ACRAF | 2010-12-08 | — | — | CN | disclosed |
| EP-1594859-B1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | ACRAF (IT) | 2010-06-23 | — | — | EP | disclosed |
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A. (IT) | 2010-02-25 | — | — | US | disclosed |
| US-7632849-B2 | N3-((1-(2-Oxo-2-(phenylamino)ethyl)-4-piperidyl)methyl)- 1-(1-methylethyl)-1H-indazole-3-carboxamide; antiarthritic agents; rheumatic diseases; osteoarthritis; fibromyaleia;anticarcinogenic agents, pain; neuropathic pain; immunoincompetance; trauma; antiischemic agents; multiple sclerosis | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-15 | — | — | US | disclosed |
| CN-101139341-A | Indazolamides with analgesic activity | ACRAF (IT) | 2008-03-12 | — | — | CN | disclosed |
| CN-100347168-C | Indazolamides with analgesic activity | ACRAF (IT) | 2007-11-07 | — | — | CN | disclosed |
| US-20060052417-A1 | Indazolamides with analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2006-03-09 | — | — | US | disclosed |
| CN-1742004-A | Indazolamides with analgesic activity | ACRAF (IT) | 2006-03-01 | — | — | CN | disclosed |
| EP-1594859-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074275-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | TRPV1, CA2, TRPV2 | ALDH1A1 571/4885MAPT 3032/4885LMNA 2839/4885 |
| US-20060052417-A1 | Indazolamides with analgesic activity | P2RX7, P2RX3, P2RX1 | ALDH1A1 870/4885MAPT 3312/4885LMNA 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.