Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899182 | 1.00 | TSHR (0.44) | TSHRALDH1A1LCKPPARDZDHHC20 | |
| SCHEMBL27848612 | 0.82 | TSHR (0.39) | TSHRALDH1A1HSD17B10MGAMGAA | |
| SCHEMBL1413253 | 0.81 | MGAM (0.44) | TSHRALDH1A1HSD17B10MGAMGAA | |
| SCHEMBL11274143 | 0.81 | ZDHHC7 (0.48) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL8896554 | 0.79 | TSHR (0.40) | TSHRALDH1A1HSD17B10MGAMGAA | |
| SCHEMBL11495744 | 0.79 | TSHR (0.40) | TSHRALDH1A1HSD17B10MGAMGAA | |
| SCHEMBL17841947 | 0.77 | ALDH1A1 (0.48) | TSHRALDH1A1LCKPPARDZDHHC20 | |
| SCHEMBL133872 | 0.77 | TSHR (0.39) | TSHRALDH1A1HSD17B10MGAMGAA | |
| SCHEMBL12451759 | 0.77 | MGAM (0.41) | TSHRALDH1A1HSD17B10MGAMGAA | |
| SCHEMBL1444812 | 0.77 | TET2 (0.39) | TSHRALDH1A1HSD17B10MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118271237-A | Substituted phenol derivative and use thereof | 成都麻沸散医药科技有限公司 | 2024-07-02 | — | — | CN | disclosed |
| EP-3086814-B1 | DRUG CONJUGATES (ADCS) WITH KINESIN SPINDEL PROTEIN (KSP) | Bayer Pharma AG (DE) | 2020-06-24 | — | — | EP | disclosed |
| US-10022453-B2 | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-07-17 | — | — | US | disclosed |
| US-20180185510-A1 | ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTI-B7H3-ANTIBODIES | Bayer Pharma AG (DE) | 2018-07-05 | — | — | US | disclosed |
| US-20180015176-A1 | ANTIBODY-DRUG CONJUGATES (ADCS) OF KSP INHIBITORS WITH AGLYCOSYLATED ANTI-TWEAKR ANTIBODIES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-18 | — | — | US | disclosed |
| US-20160346402-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH KINESIN SPINDEL PROTEIN (KSP) | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-01 | — | — | US | disclosed |
| US-20160346402-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH KINESIN SPINDEL PROTEIN (KSP) | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-01 | — | — | US | disclosed |
| WO-2016096610-A1 | ANTIBODY-DRUG CONJUGATES (ADCS) OF KSP INHIBITORS WITH AGLYCOSYLATED ANTI-TWEAKR ANTIBODIES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-06-23 | — | — | WO | disclosed |
| EP-1232157-B1 | NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF | EPOCH BIOSCIENCES INC (US) | 2010-05-05 | — | — | EP | disclosed |
| US-6972328-B2 | Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof | EPOCH BIOSCIENCES, INC. (US) | 2005-12-06 | — | — | US | disclosed |
| US-20050239121-A1 | Non-aggregating non-quenching oligomers comprising nucleotide analogs; methods of synthesis and use thereof | EPOCH BIOSCIENCES, INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20040116689-A1 | Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof | EPOCH BIOSCIENCES, INC. (US) | 2004-06-17 | — | — | US | disclosed |
| US-6660845-B1 | Peptide nucleic acids in which one or more purine bases are substituted by a pyrazolo(5,4-d)pyrimidine or by a 7-deazapurine purine analogue; improved hybridization analysis | EPOCH BIOSCIENCES, INC. | 2003-12-09 | — | — | US | disclosed |
| EP-1232157-A2 | NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF | Epoch Biosciences, Inc. (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001038584-A2 | NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF | EPOCH BIOSCIENCES, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239121-A1 | Non-aggregating non-quenching oligomers comprising nucleotide analogs; methods of synthesis and use thereof | RNGTT, PABPC4, ADAR | TSHR 3713/4885ALDH1A1 2118/4885LCK 4386/4885 |
| US-10022453-B2 | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) | KIF5B, KIF23, KIF2C | TSHR 4052/4885ALDH1A1 924/4885LCK 2753/4885 |
| US-20180185510-A1 | ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTI-B7H3-ANTIBODIES | KIF23, KIF5B, KIF2C | TSHR 3868/4885ALDH1A1 1644/4885LCK 1123/4885 |
| US-20180015176-A1 | ANTIBODY-DRUG CONJUGATES (ADCS) OF KSP INHIBITORS WITH AGLYCOSYLATED ANTI-TWEAKR ANTIBODIES | TNFSF11, TNFRSF9, CD40 | TSHR 2038/4885ALDH1A1 2346/4885LCK 1140/4885 |
| US-20160346402-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH KINESIN SPINDEL PROTEIN (KSP) | KIF5B, KIF23, KIF2C | TSHR 4052/4885ALDH1A1 924/4885LCK 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.