Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253325 | 0.90 | ALDH1A1 (0.56) | SIGMAR1ALDH1A1TSHRPOLBGAA | |
| SCHEMBL3251466 | 0.88 | MAOA (0.51) | SIGMAR1ALDH1A1TSHRPOLBHSD17B10 | |
| SCHEMBL3256385 | 0.86 | XDH (0.51) | SIGMAR1ALDH1A1TSHRPOLBGAA | |
| SCHEMBL3246823 | 0.84 | SIGMAR1 (0.73) | SIGMAR1ALDH1A1TSHRPOLBHSD17B10 | |
| SCHEMBL3255205 | 0.83 | ALDH1A1 (0.49) | SIGMAR1ALDH1A1TSHRHSD17B10RAB9A | |
| SCHEMBL13304409 | 0.82 | ALDH1A1 (0.48) | SIGMAR1ALDH1A1TSHRPOLBHSD17B10 | |
| SCHEMBL13072391 | 0.81 | LTA4H (0.42) | SIGMAR1ALDH1A1POLBHSD17B10CYP2C9 | |
| Oxazorone SCHEMBL29913823 | 0.78 | TDP1 (0.66) | ALDH1A1POLBGAAHSD17B10KDM4E | |
| Oxazorone SCHEMBL2109280 | 0.78 | TDP1 (0.66) | ALDH1A1POLBGAAHSD17B10KDM4E | |
| SCHEMBL3252433 | 0.78 | ALDH1A1 (0.57) | SIGMAR1ALDH1A1TSHRHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890672-B1 | USE OF CHROMONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-02 | — | — | EP | disclosed |
| EP-1890672-A1 | USE OF CHROMONE DERIVATIVES | Merck Patent GmbH (DE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128562-A1 | USE OF CHROMONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-12-07 | — | — | WO | disclosed |