Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835955 | 0.81 | ALDH1A1 (0.39) | ALDH1A1AURKADAPK3PDGFRALTK | |
| SCHEMBL3261626 | 0.81 | AR (0.39) | ALDH1A1AURKADAPK3PDGFRALTK | |
| SCHEMBL3262746 | 0.80 | NPC1 (0.42) | ALDH1A1GAALMNAMAPTL3MBTL1 | |
| SCHEMBL1114873 | 0.80 | HSP90AA1 (0.46) | ALDH1A1GAAPOLBMPINPC1 | |
| SCHEMBL3268349 | 0.79 | CYP2E1 (0.46) | ALDH1A1GAAMAPTL3MBTL1POLB | |
| SCHEMBL3262867 | 0.79 | ALKBH5 (0.54) | ALDH1A1GAAMAPTL3MBTL1POLB | |
| SCHEMBL10373240 | 0.78 | MAPT (0.61) | ALDH1A1GAALMNAMAPTL3MBTL1 | |
| SCHEMBL29401773 | 0.77 | ALKBH5 (0.51) | ALDH1A1AURKADAPK3PDGFRALTK | |
| SCHEMBL13860451 | 0.76 | AURKA (0.57) | ALDH1A1AURKADAPK3PDGFRALTK | |
| SCHEMBL31503514 | 0.76 | MEN1 (0.50) | ALDH1A1AURKADAPK3PDGFRALTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040817-B1 | Dyeing composition comprising a pyrazolo(1,5-a)pyrimidine and a monocyclic polyaminopyrimidine as oxidation bases and a coupler, and dyeing process | OREAL (FR) | 2005-02-02 | — | — | EP | claimed |
| CN-108409662-B | Hydroxylamine-substituted Meldrum's acid, Barbituric acid and pyrazolone derivatives as HNO donors | 约翰斯霍普金斯大学 | 2021-10-26 | — | — | CN | disclosed |
| US-9862699-B2 | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-01-09 | — | — | US | disclosed |
| EP-2776402-B1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | UNIV JOHNS HOPKINS (US) | 2017-07-26 | — | — | EP | disclosed |
| US-20170050947-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | THE JOHNS HOPKINS UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-9499511-B2 | N-substituted hydroxylamine derivatives with carbon-based leaving groups | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-11-22 | — | — | US | disclosed |
| US-20160115148-A1 | N-SUBSTITUTED HYDROXYLAMINE DERIVATIVES WITH CARBON-BASED LEAVING GROUPS | NATIONAL SCIENCE FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| US-9181213-B2 | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-11-10 | — | — | US | disclosed |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | NATIONAL SCIENCE FOUNDATION | 2014-09-18 | — | — | US | disclosed |
| CN-104053647-A | Hydroxylamine-substituted Meldrum's acid, Barbituric acid and pyrazolone derivatives as HNO donors | UNIV JOHNS HOPKINS | 2014-09-17 | — | — | CN | disclosed |
| EP-0415885-A1 | Bis-Phthalideactones, process for their preparation, and their use in recording materials | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| EP-0377406-A1 | Pressure-sensitive or heat-sensitive recording material | CIBA-GEIGY AG (CH) | 1990-07-11 | — | — | EP | disclosed |
| EP-0373110-A2 | Pressure-sensitive or heat-sensitive recording material | CIBA-GEIGY AG (CH) | 1990-06-13 | — | — | EP | disclosed |
| US-4933448-A | FOR PRESSURE OR HEAT SENSITIVE RECORDING MATERIALS | CIBA-GEIGY CORPORATION (US) | 1990-06-12 | — | — | US | disclosed |
| EP-0185909-B1 | 5-ALKYL-1-PHENYL-2-PIPERAZINO ALKYLPYRAZOLIN-3-ONE COMPOUNDS AS WELL AS PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Kali-Chemie Pharma GmbH (DE) | 1990-02-21 | — | — | EP | disclosed |
| EP-0340169-A2 | Chromogenic lactone compounds of benzopyrano-2H-pyrazoles | CIBA-GEIGY AG (CH) | 1989-11-02 | — | — | EP | disclosed |
| US-4672063-A | Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds | KALI-CHEMIE PHARMA GMBH (DE) | 1987-06-09 | — | — | US | disclosed |
| US-4617258-A | WATER SOLUBLE GROUP 8 COMPOUNDS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-10-14 | — | — | US | disclosed |
| EP-0185909-A1 | 5-Alkyl-1-phenyl-2-piperazino alkylpyrazolin-3-one compounds as well as processes and intermediates for their preparation and medicaments containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |
| EP-0091788-A2 | Silver halide photographic material | KONICA CORPORATION (JP) | 1983-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050947-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | HMOX1, HMOX2, HPGD | ALDH1A1 515/4885AURKA 2859/4885DAPK3 1574/4885 |
| US-20160115148-A1 | N-SUBSTITUTED HYDROXYLAMINE DERIVATIVES WITH CARBON-BASED LEAVING GROUPS | NOS2, NOS3, HMOX2 | ALDH1A1 453/4885AURKA 3957/4885DAPK3 1659/4885 |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | HMOX1, HMOX2, HPGD | ALDH1A1 515/4885AURKA 2859/4885DAPK3 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.