SCHEMBL32688144

SCHEMBL32688144

COc1ccc(-c2nc(=O)[nH]c(SCc3nnn[nH]3)c2C#N)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ HPGD P15428 4/20 0.44
▸ CXCR2 P25025 1/20 0.44
▸ ALDH1A1 P00352 6/20 0.42
▸ HTT P42858 2/20 0.42
▸ ADORA1 P30542 4/20 0.42
▸ KDM4E B2RXH2 3/20 0.41
▸ LMNA P02545 1/20 0.41
▸ ADORA2A P29274 3/20 0.40
▸ ADORA2B P29275 2/20 0.40
▸ ADORA3 P0DMS8 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ CA12 O43570 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ CA9 Q16790 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ MAPT P10636 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688043 0.88 LMNA (0.45) MEN1KMT2ACXCR2ALDH1A1LMNA
SCHEMBL32688268 0.87 MEN1 (0.42) MEN1KMT2AHPGDCXCR2ALDH1A1
SCHEMBL32688366 0.87 ACMSD (0.47) MEN1KMT2AHPGDCXCR2ALDH1A1
SCHEMBL32688407 0.86 ACMSD (0.39) MEN1KMT2AHPGDCXCR2ALDH1A1
SCHEMBL32688285 0.84 POLB (0.40) MEN1KMT2ACXCR2ADORA1LMNA
SCHEMBL32687967 0.83 MEN1 (0.43) MEN1KMT2ACXCR2LMNACA12
SCHEMBL32687990 0.82 ADORA1 (0.44) MEN1KMT2AHPGDCXCR2ALDH1A1
SCHEMBL32688157 0.80 MEN1 (0.46) MEN1KMT2ACXCR2ADORA1ADORA2A
SCHEMBL32688267 0.80 ADORA1 (0.40) MEN1KMT2AHPGDCXCR2ALDH1A1
SCHEMBL32688228 0.78 HSD11B1 (0.40) MEN1KMT2AHPGDCXCR2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK MEN1 4353/4885KMT2A 3400/4885HPGD 431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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