SCHEMBL32688228

SCHEMBL32688228

N#Cc1c(-c2ccccc2Cl)nc(=O)[nH]c1SCc1nnn[nH]1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 11/20 0.40
▸ BRD4 O60885 3/20 0.39
▸ CXCR2 P25025 1/20 0.39
▸ ADORA2A P29274 1/20 0.35
▸ ADORA1 P30542 1/20 0.35
▸ MEN1 O00255 4/20 0.35
▸ KMT2A Q03164 4/20 0.35
▸ POLB P06746 3/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ STAT6 P42226 1/20 0.35
▸ HIF1A Q16665 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688294 0.88 MEN1 (0.41) HSD11B1MEN1KMT2APOLBKDM4E
SCHEMBL32688366 0.86 ACMSD (0.47) HSD11B1BRD4CXCR2ADORA2AADORA1
SCHEMBL32688043 0.83 LMNA (0.45) HSD11B1BRD4CXCR2MEN1KMT2A
SCHEMBL32687967 0.83 MEN1 (0.43) HSD11B1BRD4CXCR2MEN1KMT2A
SCHEMBL32688157 0.82 MEN1 (0.46) HSD11B1BRD4CXCR2ADORA2AADORA1
SCHEMBL32688407 0.81 ACMSD (0.39) HSD11B1BRD4CXCR2ADORA2AADORA1
SCHEMBL32688268 0.80 MEN1 (0.42) HSD11B1BRD4CXCR2ADORA2AADORA1
SCHEMBL32688267 0.80 ADORA1 (0.40) HSD11B1BRD4CXCR2ADORA2AADORA1
SCHEMBL32688050 0.79 HSD11B1 (0.44) HSD11B1BRD4CXCR2POLBKDM4E
SCHEMBL32688258 0.78 HSD11B1 (0.38) HSD11B1CXCR2MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK HSD11B1 61/4885BRD4 3710/4885CXCR2 2082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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