Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Duloxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 13/20 | 0.87 |
| ▸ | SLC6A4 known ✓ | P31645 | 13/20 | 0.87 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.87 |
| ▸ | MLNR | O43193 | 1/20 | 0.87 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | HTR1A | P08908 | 1/20 | 0.87 |
| ▸ | GAA | P10253 | 1/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.87 |
| ▸ | DRD2 | P14416 | 1/20 | 0.87 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.87 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.87 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 1/20 | 0.87 |
| ▸ | HTR2C | P28335 | 1/20 | 0.87 |
| ▸ | MC4R | P32245 | 1/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Duloxetine SCHEMBL3896385 | 1.00 | SLC6A2 (0.87) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL308488 | 1.00 | SLC6A2 (0.87) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL2120068 | 0.96 | SLC6A2 (0.87) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL4573554 | 0.95 | SLC6A2 (0.85) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL309402 | 0.94 | SLC6A2 (0.83) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL2109339 | 0.94 | SLC6A2 (0.87) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL991500 | 0.93 | SLC6A2 (0.95) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL3803 | 0.93 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL3398599 | 0.93 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F | |
| Duloxetine SCHEMBL8291 | 0.93 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3MLNRCACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100432069-C | 3-methylamino-1- (2-thienyl) -1-acetone and preparation and application thereof | BASF AG (DE) | 2008-11-12 | — | — | CN | claimed |
| EP-1587802-B1 | PRODUCTION AND USE OF 3-METHYLAMINO-1-(2-THIENYL)-1-PROPANONE | BASF AG (DE) | 2007-11-14 | — | — | EP | claimed |
| US-20060128791-A1 | 3-Methylamino-1-(2-thienyl)-1-propanone, production and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 2006-06-15 | — | — | US | claimed |
| CN-1742003-A | 3-methylamino-1-(2-thienyl)-1-propanone, production and use thereof | BASF AG (DE) | 2006-03-01 | — | — | CN | claimed |
| US-8362279-B2 | Process for pure duloxetine hydrochloride | MSN LABORATORIES LIMITED (IN) | 2013-01-29 | — | — | US | disclosed |
| US-20110230666-A1 | PROCESS FOR THE SEPARATION OF ENANTIOMERICALLY PURE COMPOUNDS | SHODHANA LABORATORIES LIMITED (IN) | 2011-09-22 | — | — | US | disclosed |
| WO-2011077443-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE | BIOCON LIMITED (IN) | 2011-06-30 | — | — | WO | disclosed |
| US-20100280093-A1 | PROCESS FOR THE PREPARATION ENANTIOMERICALLY PURE SALTS OF N-METHYL-3-(1-NAPHTHALENEOXY)-3-(2-THIENYL)PROPANAMINE | RANBAXY LABORATORIES LIMITED (IN) | 2010-11-04 | — | — | US | disclosed |
| EP-1857451-B1 | A process for the preparation of an intermediate useful for the asymmetric synthesis of (+)duloxetine | FIDIA FARMACEUTICI (IT) | 2010-07-21 | — | — | EP | disclosed |
| EP-2016066-A2 | PROCESS FOR PREPARING DULOXETINE | Dr. Reddy's Laboratories Ltd. (IN) | 2009-01-21 | — | — | EP | disclosed |
| US-20090012315-A1 | Process for Pure Duloxetine Hydrochloride | MSN LABORATORIES LIMITED (IN) | 2009-01-08 | — | — | US | disclosed |
| CN-100432069-C | 3-methylamino-1- (2-thienyl) -1-acetone and preparation and application thereof | BASF AG (DE) | 2008-11-12 | — | — | CN | disclosed |
| CN-1742003-A | 3-methylamino-1-(2-thienyl)-1-propanone, production and use thereof | BASF AG (DE) | 2006-03-01 | — | — | CN | disclosed |
| EP-1587802-A1 | 3-METHYLAMINO-1-(2-THIENYL)-1-PROPANONE, PRODUCTION AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004065376-A1 | 3-METHYLAMINO-1-(2-THIENYL)-1-PROPANONE, PRODUCTION AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2004-08-05 | — | — | WO | disclosed |
| EP-0457559-A2 | Chiral synthesis of 1-aryl-3-aminopropan-1-ols | ELI LILLY AND COMPANY (US) | 1991-11-21 | — | — | EP | disclosed |
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230666-A1 | PROCESS FOR THE SEPARATION OF ENANTIOMERICALLY PURE COMPOUNDS | HTR5A, ACHE, CHRNA5 | SLC6A2 23/4885SLC6A4 15/4885SLC6A3 79/4885 |
| US-20100280093-A1 | PROCESS FOR THE PREPARATION ENANTIOMERICALLY PURE SALTS OF N-METHYL-3-(1-NAPHTHALENEOXY)-3-(2-THIENYL)PROPANAMINE | PNMT, HTR3A, CHRNA3 | SLC6A2 5/4885SLC6A4 13/4885SLC6A3 8/4885 |
| US-20090012315-A1 | Process for Pure Duloxetine Hydrochloride | OPRK1, OPRM1, OPRD1 | SLC6A2 6/4885SLC6A4 5/4885SLC6A3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.