Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430749 | 0.92 | GAA (0.43) | DHODHCHEK2CYP1A2 | |
| SCHEMBL3353013 | 0.83 | DHODH (0.45) | DHODHPTGDR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3346002 | 0.83 | GRIN2D (0.41) | DHODHCHEK2CYP1A2 | |
| SCHEMBL4727593 | 0.80 | KDM4E (0.41) | CYP1A2POLBCYP2C9TSHR | |
| SCHEMBL3346086 | 0.78 | PTGER4 (0.44) | DHODHCYP2C9 | |
| SCHEMBL3350676 | 0.75 | DHODH (0.43) | DHODHMCL1EZH2 | |
| SCHEMBL3347753 | 0.73 | DHODH (0.41) | DHODHCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3431063 | 0.69 | ALDH1A1 (0.39) | CHEK2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4660837 | 0.67 | KDM4E (0.36) | CYP1A2POLBCYP3A4CYP2C9TSHR | |
| SCHEMBL3415925 | 0.63 | CHEK2 (0.44) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |